Douglas A. Kuperman, PhD, Christina C. Lewis, PhD, Prescott G

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Presentation transcript:

Dissecting asthma using focused transgenic modeling and functional genomics Douglas A. Kuperman, PhD, Christina C. Lewis, PhD, Prescott G. Woodruff, MD, Madeleine W. Rodriguez, BS, Yee Hwa Yang, PhD, Gregory M. Dolganov, PhD, John V. Fahy, MD, David J. Erle, MD Journal of Allergy and Clinical Immunology Volume 116, Issue 2, Pages 305-311 (August 2005) DOI: 10.1016/j.jaci.2005.03.024 Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Lung gene expression changes in 3 mouse asthma models. Differentially expressed genes were arranged by hierarchical clustering. Each column represents data from 1 of 5 individual mice in each group. Colors represent fold-change compared with the appropriate controls. The arrow indicates a small group of genes that were increased in all 3 models. Ova, Ovalbumin. Journal of Allergy and Clinical Immunology 2005 116, 305-311DOI: (10.1016/j.jaci.2005.03.024) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Gene expression patterns. Grouping revealed genes with increased expression in (A) the ovalbumin (Ova) model only, (B) the Ova and tg–IL-13 models, (C) the tg–IL-13 model only, and (D) all 3 models. The number of genes (left) and representative genes (right) is shown for each group. Phenotypic attributes of each model are shown at the bottom. AHR, Airway hyperreactivity. Journal of Allergy and Clinical Immunology 2005 116, 305-311DOI: (10.1016/j.jaci.2005.03.024) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Intelectin (Itln) expression in human airway epithelial cells. A, Intelectin gene expression by airway epithelial cells from control subjects and subjects with asthma. Medians and interquartile ranges are shown. B, IL-13 treatment of cultured human airway epithelial cells induced increased expression of intelectin transcripts. Journal of Allergy and Clinical Immunology 2005 116, 305-311DOI: (10.1016/j.jaci.2005.03.024) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions