Metastatic glucagonoma: Treatment with liver transplantation

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Presentation transcript:

Metastatic glucagonoma: Treatment with liver transplantation Peter Radny, MD, Thomas Kurt Eigentler, MD, Karsten Soennichsen, MD, Dietrich Overkamp, MD, Hans-Rudolf Raab, MD, Richard Viebahn, MD, Christian Mueller-Horvart, MD, Karl Sotlar, MD, Gernot Rassner, MD Journal of the American Academy of Dermatology Volume 54, Issue 2, Pages 344-347 (February 2006) DOI: 10.1016/j.jaad.2005.05.023 Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Skin examination revealed disseminated, scaly, erythematous, circinate, and serpiginous plaques. Plaques were present mainly on perioral area, knees, ventral aspect of chest, gluteal and genitocrural regions, and extremities. Journal of the American Academy of Dermatology 2006 54, 344-347DOI: (10.1016/j.jaad.2005.05.023) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Arrowheads show two of the multiple liver metastases in contrast-enhanced computed tomographic scan of abdomen. Journal of the American Academy of Dermatology 2006 54, 344-347DOI: (10.1016/j.jaad.2005.05.023) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 Liver metastasis of the glucagonoma. At left, circumscribed metastatic glucagonoma tissue is seen with adjacent normal liver tissue (right). Metastatic tumor is composed of small relatively uniform cells with ovoid nuclei that show a gyriform growth pattern. (Hematoxylin-eosin stain; original magnification ×200.) Journal of the American Academy of Dermatology 2006 54, 344-347DOI: (10.1016/j.jaad.2005.05.023) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

Fig 4 Metastatic glucagonoma. Immunohistochemical detection of strong cytoplasmic expression of glucagon in approximately 50% of tumor cells. (Antiglucagon stain [Biogenics]; original magnification ×400.) Journal of the American Academy of Dermatology 2006 54, 344-347DOI: (10.1016/j.jaad.2005.05.023) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

Fig 5 Somatostatin receptor scintigraphy of abdomen 4 hours after injection of 198 MBq indium 111–labeled octreotide. Somatostatin receptor–positive lesions in liver show intense uptake. RVL, Right ventral left (anterior view); LDR, left dorsal right (posterior view). Journal of the American Academy of Dermatology 2006 54, 344-347DOI: (10.1016/j.jaad.2005.05.023) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions