Periprosthetic knee joint infection of a patient with a history of clinical and infectious laboratory parameters for 2 weeks. Periprosthetic knee joint infection of a patient with a history of clinical and infectious laboratory parameters for 2 weeks. A two-stage revision was performed. (A and B) X-rays without specific changes. (C) Clinical presentation 2 to 3 weeks after the first symptoms occurred. Inflamed skin with draining pus after incision of the skin (black arrow) can be seen. (D) S. aureus colonies grown from a specimen of chronically infected bone tissue. On the Columbia blood agar plate, a high phenotypic diversity of large (black arrow), small, and very small (white arrow) phenotypes, which represent dynamic SCVs, is visible. (Panels A, B, and C courtesy of W. Kluge, Hufeland-Klinikum Weimar, Germany; reprinted with permission.) Barbara C. Kahl et al. Clin. Microbiol. Rev. 2016; doi:10.1128/CMR.00069-15