Electron microscopy of SorLA intracellular localization.

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Electron microscopy of SorLA intracellular localization. Electron microscopy of SorLA intracellular localization. Ultrathin cryosections of HEK-293 SorLA cells were immuno-gold-labeled with the mouse anti-SorLA antibody. The gold size used for the immuno-labeling is indicated by the superscript number. The upper panel shows an overview of SorLA labeling in transfected HEK-293 cells. SorLA staining is primarily found in the Golgi and endosomes. The lower panels show enlarged pictures of endosomes. EEs and MVB/LEs have been defined as described previously (Mari et al., 2008). SorLA is found in the limiting membrane and inside EEs and late endosomes (LE), and in dense tubular structures in close vicinity to EEs (arrows). Scale bars: 100 nm. L, lysosomes; M, mitochondria; PM, plasma membrane. Stine C. Klinger et al. J Cell Sci 2011;124:1095-1105 © 2011.