Regulation of Bcl-2 family proteins in the hypothalamus of non-diabetic and diabetic IRS2−/− mice. Regulation of Bcl-2 family proteins in the hypothalamus.

Slides:

Advertisements

Similar presentations

Adamtsl2 targeting strategy and validation of inactivation.

Advertisements

VacA does not induce phosphorylation of Src in RPTPα constitutive-knockdown AZ-521 cells. VacA does not induce phosphorylation of Src in RPTPα constitutive-knockdown.

Total and differential cell counting in the broncho-alveolar lavage of mice exposed to CS or air during 3 or 6 months. Total and differential cell counting.

Representative histological images of aorta from WT, ApoEm/m and ApoE−/− pigs. Representative histological images of aorta from WT, ApoEm/m and ApoE−/−

Tomoregulin-1 improves cardiac pathological changes after pressure overload. Tomoregulin-1 improves cardiac pathological changes after pressure overload.

Discordance and similarity between humans with FA and FA mouse models.

Crotonate prevents downregulation of kidney PGC-1α and SIRT3 as well as causing CCL2 upregulation in experimental AKI. AKI was induced by a folic acid.

Crotonate increases histone crotonylation in mouse kidney.

Effect of OLHHA on the protein expression of relevant enzymes and factors related to lipid metabolism in the liver of obese Zucker rats. Effect of OLHHA.

Concentration of biomarkers of haemostasis.

TP53 western blot of primary cultured tail cells from both wild-type (WT) and Tp53Δ11/Δ11 (−/−) rats. TP53 western blot of primary cultured tail cells.

Tomoregulin-1 inhibits the TGFβ non-canonical (TAK1-JNK) pathways after pressure overload. Tomoregulin-1 inhibits the TGFβ non-canonical (TAK1-JNK) pathways.

Expression of tomoregulin-1 in wild-type and cardiac hypertrophy mouse myocardium. Expression of tomoregulin-1 in wild-type and cardiac hypertrophy mouse.

Survival and telomere length of G2tert−/− zebrafish in a p53−/− background. Survival and telomere length of G2tert−/− zebrafish in a p53−/− background.

Hypoacidity, anemia and hypergastrinemia in KI/KI mice.

Secondary storage of GM2 ganglioside and cholesterol in Fuca1-deficient mice. Secondary storage of GM2 ganglioside and cholesterol in Fuca1-deficient mice.

TWEAK downregulates SIRT3 in cultured tubular cells and this is prevented by crotonate. TWEAK downregulates SIRT3 in cultured tubular cells and this is.

Obesity affected the metabolic response to stroke.

Expression data confirm and extend existing knowledge

Elevated pAkt level in ptena−/−ptenb−/− mutants is suppressed by LY and to a lesser extent by sunitinib. Elevated pAkt level in ptena−/−ptenb−/−

Effects of doxorubicin and epirubicin on proliferation and apoptosis in the hyperplastic livers of transgenic zebrafish larvae. Effects of doxorubicin.

FAK tyrosine phosphorylation is unaffected by loss of LAR activity.

Superimposed traces representing the effects of different concentrations of adrenaline on AP characteristics. Superimposed traces representing the effects.

Tamoxifen injections induce DNA damage response signaling in αMHC-MerCreMer mice.αMHC-MerCreMer+/+ mice received an injection of 60 μg/g body weight of.

Tamoxifen injections in αMHC-MerCreMer mice induce a loxP-independent DNA damage response, leading to myocardial dysfunction and death. Tamoxifen injections.

Fig. 1. TSA at 165 nM induces maximal acetylation of histone H3 and near-maximal acetylation of histone H4.Immunoblot analysis of acetylated histones H3.

Elevated expression of vegfaa in hemangiosarcoma.

The effect of TDP-43A315T expression on dendrite spine development.

Distribution and extent of expression.

Intestinal CAV1 deletion alters circulating FFAs but not TGs

The genomic distribution of essential and non-essential mouse genes, separated into known and predicted essentiality. The genomic distribution of essential.

Detection of gene recombination in endoxifen- or Adeno-Cre-induced tumours. Detection of gene recombination in endoxifen- or Adeno-Cre-induced tumours.

Chronic phenytoin increases activity levels in Mecp2Null/Y mice.

2DG downregulates the expression of HIF-1α, PDK1 and c-Myc in NB xenograft. 2DG downregulates the expression of HIF-1α, PDK1 and c-Myc in NB xenograft.

Ang-1, ESE-1 and Tie-2 expression levels during teratogen-induced CDH

Lamin B1 is regulated developmentally.

Tissue ATP levels measured in the liver, muscle, kidney and pancreas of CDs/y and CDr/y on RD or DD. *P

Increased expression of the drusen-associated genes (ApoE, ApoJ, ApoB and App) and Vegfa in the RPE/retina of Pgc-1α+/− mice under RD and HFD. (A) The.

Macrophage-produced IL-10 is required but not sufficient for macrophage-stimulated proliferation of ADPKD cells. Macrophage-produced IL-10 is required.

Tamoxifen injections cause dose-dependent lethal heart failure in αMHC-MerCreMer mice. Tamoxifen injections cause dose-dependent lethal heart failure in.

Fig. 1. PARN is differentially expressed in breast cancer versus non-cancerous tissue/cells. PARN is differentially expressed in breast cancer versus non-cancerous.

Effect of Dipy on the expression of chondrogenic markers.

Nerve conduction slowing and DRG sensory neuron and nuclear atrophy in 16-week-old diabetic mice. Nerve conduction slowing and DRG sensory neuron and nuclear.

Expression of transgenic IGF-1Ea propeptide in the skin reduces the severity of contact hypersensitivity responses. Expression of transgenic IGF-1Ea propeptide.

Food-additive exposure increases permeability in a human gut cell co-culture model. Food-additive exposure increases permeability in a human gut cell co-culture.

Effect of γ-secretase inhibition on the vulnerability of primary neurons to OGD. (A) Experimental design. Effect of γ-secretase inhibition on the vulnerability.

Anti-epileptic drugs with Na+ channel blocking activity improve QTc in individuals with Rett syndrome. Anti-epileptic drugs with Na+ channel blocking activity.

Angiotensin-(1-7) activates the IGF-1/Akt signalling pathway during muscle disuse through the Mas receptor. Angiotensin-(1-7) activates the IGF-1/Akt signalling.

Cross-validation between centres for inbred mice.

Therapeutic delivery of rhIGF-1 reduces the severity of contact hypersensitivity responses. Therapeutic delivery of rhIGF-1 reduces the severity of contact.

Pgc-1α+/− mice show an increased inflammatory response to LPS injection. Pgc-1α+/− mice show an increased inflammatory response to LPS injection. (A) RPE/retina.

Light-dark cycles modulate neurodegeneration in bgm and dbb single mutants. Light-dark cycles modulate neurodegeneration in bgm and dbb single mutants.

IRS-1 and -2 expression in four mesangial cell lines from different D-NOD (A and B) and ND-NOD (C and D) mice. IRS-1 and -2 expression in four mesangial.

Immunoblotting samples (A and F) and densitometric analysis of ASC1 (B and G), NLRP3 (C and H), TNFα (D and I) and Caspase-1 (E and J) expression in the.

Microarray analysis of DRG explant cultures of wild-type and ErbB3-deficient mice. Microarray analysis of DRG explant cultures of wild-type and ErbB3-deficient.

Examples of tumors represented in Tp53Δ11/Δ11 and Tp53Δ11/+ rats.

Effect of the siRNA-mediated knockdown of endogenous MARCH8 on the expression levels of MARCH8 substrates, TfR and CD98, in HepG2 cells. Effect of the.

A-E: Bcl family gene regulation in human islets cultured in high versus normal glucose. A-E: Bcl family gene regulation in human islets cultured in high.

A-N: Immunofluorescence analysis of Bcl family genes in human islets of Langerhans. A-N: Immunofluorescence analysis of Bcl family genes in human islets.

KIF13A depletion leads to a drop in virus titers, without affecting viral protein expression. KIF13A depletion leadsto a drop in virus titers, without.

Peroxisome speeds were slower in patient and control cells.

Spatial and temporal distribution of autofluorescent (AF) spots and rosettes in rd7 mice. Spatial and temporal distribution of autofluorescent (AF) spots.

Small molecule suppression of ATXN3-CAG89 aggregation.

Fig. 7. Nrf2-dependent enzyme activities in wild-type, Nrf2- and Keap1-deficient tissues.Hepatic (A,C,E) and cortical (B,D,F) enzyme activities of NQO1.

MMP expression at the growth plate.

Inhibition of macrophage STAT3 activation during ADPKD programming blunts development of the pathological pro-proliferative macrophage phenotype. Inhibition.

Functional and molecular regeneration in mdx muscle with matrix treatment. Functional and molecular regeneration in mdx muscle with matrix treatment. (A,B)

Ca2+-mediated differentiation of primary mouse keratinocytes is independent of epiplakin. Ca2+-mediated differentiation of primary mouse keratinocytes.

Upon challenge with oxazolone, human leukocytes (mainly consisting of T cells) infiltrate the dermis and epidermis. Upon challenge with oxazolone, human.

Ctip2 directly regulates Notch1 expression in differentiated cells.

Presentation transcript:

Regulation of Bcl-2 family proteins in the hypothalamus of non-diabetic and diabetic IRS2−/− mice. Regulation of Bcl-2 family proteins in the hypothalamus of non-diabetic and diabetic IRS2−/− mice. Immunoblots probed with antibodies against Bcl-2 (A), Bcl-xL (B), BAD (C), BID (D) and BIM (E) in the hypothalamus of wild-type (WT), non-diabetic IRS2-deficient (ND IRS2−/−) and diabetic IRS2-deficient (D IRS2−/−) mice. (F) Representative immunoblotos for Bcl-2, Bcl-xL, BAD, BID, BIM and GAPDH. Data are presented as means±s.e.m. Statistical significance by ANOVA: *P<0.05 vs WT mice; n=6/group. Eva Baquedano et al. Dis. Model. Mech. 2016;9:573-583 © 2016. Published by The Company of Biologists Ltd