Interleukin-6 Enhances Whereas Tumor Necrosis Factor α and Interferons Inhibit Integrin Expression and Adhesion of Human Mast Cells to Extracellular Matrix.

Slides:

Advertisements

Similar presentations

Volume 9, Issue 1, Pages (January 2007)

Advertisements

Dermal CD14+ Dendritic Cell and Macrophage Infection by Dengue Virus Is Stimulated by Interleukin-4 Evelyne Schaeffer, Vincent Flacher, Vasiliki Papageorgiou,

Topical Treatment with Liposomes Containing T4 Endonuclease V Protects Human Skin In Vivo from Ultraviolet-Induced Upregulation of Interleukin-10 and.

Topical Treatment with Liposomes Containing T4 Endonuclease V Protects Human Skin In Vivo from Ultraviolet-Induced Upregulation of Interleukin-10 and.

Tumor Necrosis Factor α Increases and α-Melanocyte-Stimulating Hormone Reduces Uveal Melanoma Invasion Through Fibronectin Irene Cantón, Paula C. Eves,

Interleukin-17 and Interferon-γ Synergize in the Enhancement of Proinflammatory Cytokine Production by Human Keratinocytes Marcel B.M. Teunissen, Jan.

Yiping Wang, Yuet-Ching Tay, David C.H. Harris Kidney International

Unraveling the Pros and Cons of Interferon-γ Gene Regulation

Dysregulation of LDL receptor under the influence of inflammatory cytokines: A new pathway for foam cell formation1 Dr Xiong Z. Ruan, Zac Varghese, Stephen.

Richard L. Gallo, Jamie J. Bernard

A Fibrogenic Cytokine, Platelet-Derived Growth Factor (PDGF), Enhances Mast Cell Growth Indirectly Via a SCF- and Fibroblast-Dependent Pathway Takaaki.

IL-31 Receptor Alpha Expression in Epidermal Keratinocytes Is Modulated by Cell Differentiation and Interferon Gamma Ruth Heise, Mark M. Neis, Yvonne.

Circulating Th17, Th22, and Th1 Cells Are Increased in Psoriasis

Iontophoresis and Sonophoresis Stimulate Epidermal Cytokine Expression at Energies That Do Not Provoke a Barrier Abnormality: Lamellar Body Secretion.

Kavitha K. Reddy Journal of Investigative Dermatology

Toll-Like Receptor 3 Increases Allergic and Irritant Contact Dermatitis Naomi Nakamura, Risa Tamagawa-Mineoka, Mayumi Ueta, Shigeru Kinoshita, Norito.

Ultraviolet Light and Interleukin-10 Modulate Expression of Cytokines by Transformed Human Dermal Microvascular Endothelial Cells (HMEC-1) Thomas Scholzen,

Stuart J. Mills, Jason J. Ashworth, Stephen C. Gilliver, Matthew J

Circulating Tumor Cells and Melanoma Progression

Supriya Kapas, Paula M. Farthing Journal of Investigative Dermatology

Cannabinoid Reduces Inflammatory Cytokines, Tumor Necrosis Factor-α, and Type I Interferons in Dermatomyositis In Vitro Elizabeth S. Robinson, Paul Alves,

Inter-Regulation of Th17 Cytokines and the IL-36 Cytokines In Vitro and In Vivo: Implications in Psoriasis Pathogenesis Yijun Carrier, Hak-Ling Ma, Hilda.

Pharmacodynamic Effects of the Murine p75-Fc Fusion Protein in Mice

Human Skin Mast Cells Express H2 and H4, but not H3 Receptors

Advanced Inhibition of Undesired Human Hair Growth by PPARγ Modulation? Yuval Ramot, Arianna Mastrofrancesco, Erika Herczeg-Lisztes, Tamás Bíró, Mauro.

Clinical Snippets Journal of Investigative Dermatology

Minutes of the Board of Directors Meeting

Star Trek Publishing Journal of Investigative Dermatology

Arsenic Induces Tumor Necrosis Factor α Release and Tumor Necrosis Factor Receptor 1 Signaling in T Helper Cell Apoptosis Hsin-Su Yu, Gwo-Shing Chen

Dermatopontin Expression is Decreased in Hypertrophic Scar and Systemic Sclerosis Skin Fibroblasts and is Regulated by Transforming Growth Factor-β1,

Journal of Investigative Dermatology

Journal of Investigative Dermatology

Mast Cell–Fibroblast Interactions: Human Mast Cells as Source and Inducers of Fibroblast and Epithelial Growth Factors Metin Artuc, U. Muscha Steckelings,

Increased Expression of Endothelial Cell Adhesion Molecules Due to Mediator Release from Human Foreskin Mast Cells Stimulated by Autoantibodies in Chronic.

Society for Investigative Dermatology 2010 Meeting Minutes

Democratizing the Clinical Trials Agenda in Dermatology

Transfer of CD8+ Cells Induces Localized Hair Loss Whereas CD4+/CD25− Cells Promote Systemic Alopecia Areata and CD4+/CD25+ Cells Blockade Disease Onset.

BJD Editor's Choice Journal of Investigative Dermatology

Fibronectin at Select Sites Binds Multiple Growth Factors and Enhances their Activity: Expansion of the Collaborative ECM-GF Paradigm Jia Zhu, Richard.

Angiopoietin-1 Reduces H2O2-Induced Increases in Reactive Oxygen Species and Oxidative Damage to Skin Cells Nesreen S. Ismail, Elke A. Pravda, Dan Li,

Staphylococcus epidermidis Sets Things Right Again

Smad3 Signal Transducer Regulates Skin Inflammation and Specific IgE Response in Murine Model of Atopic Dermatitis Minna Anthoni, Guoying Wang, Chuxia.

Research Snippets Journal of Investigative Dermatology

Journal of Investigative Dermatology

Double-Stranded RNA-Exposed Human Keratinocytes Promote Th1 Responses by Inducing a Type-1 Polarized Phenotype in Dendritic Cells: Role of Keratinocyte-Derived.

Expression of Mast Cell Growth Modulating and Chemotactic Factors and their Receptors in Human Cutaneous Scars Barbara Hermes Journal of Investigative.

Research Snippets from the British Journal of Dermatology

Torsten Zuberbier, Beate M. Henz

TLR3: A Receptor that Recognizes Cell Injury Is Essential for Permeability Barrier Homeostasis Following UV Irradiation Kenneth R. Feingold Journal.

25 Years of Epidermal Stem Cell Research

John W. Haycock, Mark Wagner, Sheila Mac Neil

The Primary Cilium: A Small Yet Mighty Organelle

Frank O. Nestle, Curdin Conrad Journal of Investigative Dermatology

Keratinocytes Inhibit Expression of Connective Tissue Growth Factor in Fibroblasts In Vitro by an Interleukin-1α-Dependent Mechanism Daniel Nowinski,

Blazej Zbytek, Andrzej T. Slominski

Research Snippets Journal of Investigative Dermatology

Journal of Investigative Dermatology

Astrid Kehlen Journal of Investigative Dermatology

Naoko Kanda, Shinichi Watanabe Journal of Investigative Dermatology

The Modulation of Aromatase and Estrogen Receptor Alpha in Cultured Human Dermal Papilla Cells by Dexamethasone: A Novel Mechanism for Selective Action.

CLINICAL SNIPPETS Journal of Investigative Dermatology

Journal of Investigative Dermatology

Journal of Investigative Dermatology

The Environment and Human Health

Differential Effects of Cytokines and Immunosuppressive Drugs on CD40, B7–1, and B7–2 Expression on Purified Epidermal Langerhans Cells Claudio Guedes.

Interleukin-4 Suppresses the Enhancement of Ceramide Synthesis and Cutaneous Permeability Barrier Functions Induced by Tumor Necrosis Factor-α and interferon-γ.

Induction of Matrix Metalloproteinase-9 in Keratinocytes by Histamine

Regulation of IL-13 Receptors in Human Keratinocytes

The Majority of Epidermal T Cells in Psoriasis Vulgaris Lesions can Produce Type 1 Cytokines, Interferon-γ, Interleukin-2, and Tumor Necrosis Factor-α,

Frances L. Shaw, Marie Cumberbatch, C

Presentation transcript:

Interleukin-6 Enhances Whereas Tumor Necrosis Factor α and Interferons Inhibit Integrin Expression and Adhesion of Human Mast Cells to Extracellular Matrix Proteins Dagmar Schoeler, Andreas Grützkau, Beate M. Henz, Jens Küchler, Sabine Krüger-Krasagakis Journal of Investigative Dermatology Volume 120, Issue 5, Pages 795-801 (May 2003) DOI: 10.1046/j.1523-1747.2003.12126.x Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 mRNA expression of integrins in HMC-1 cells (representative data from one of three experiments).Lane 1, 1 kb ladder; lane 2, α1 integrin; lane 3, α2 integrin; lane 4, α3 integrin; lane 5, α4 integrin; lane 6, α5 integrin; lane 7, α6 integrin; lane 8, αv integrin; lane 9, β1 integrin; lane 10, negative control (water); lane 11, 100 bp ladder. Journal of Investigative Dermatology 2003 120, 795-801DOI: (10.1046/j.1523-1747.2003.12126.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 mRNA analysis of integrins after exposure of mast cells to different cytokines (representative data from one of five experiments). Journal of Investigative Dermatology 2003 120, 795-801DOI: (10.1046/j.1523-1747.2003.12126.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Modulation of mast cell adhesion to matrix proteins by cytokines and corticosteroids. Data show the mean±SD of the percentage change of adhesion in comparison to untreated control cells, out of five different experiments. *p<0.05 and **p<0.001, using the paired t test. Journal of Investigative Dermatology 2003 120, 795-801DOI: (10.1046/j.1523-1747.2003.12126.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 4 FACS analysis, demonstrating expression of TNF receptors I and II as well as of IL-6 receptors I and II on unstimulated HMC-1 cells. Data show one of two representative experiments. Journal of Investigative Dermatology 2003 120, 795-801DOI: (10.1046/j.1523-1747.2003.12126.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 5 mRNA expression of the receptors shown in Figure 4 and in addition of glucocorticoid receptors on unstimulated HMC-1 cells. Journal of Investigative Dermatology 2003 120, 795-801DOI: (10.1046/j.1523-1747.2003.12126.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions