Direct injection of vascular endothelial growth factor into the ovary of mice promotes follicular development Ramiro Quintana, M.D., Laura Kopcow, M.D.,

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Direct injection of vascular endothelial growth factor into the ovary of mice promotes follicular development Ramiro Quintana, M.D., Laura Kopcow, M.D., Carlos Sueldo, M.D., Guillermo Marconi, M.D., Nidia Gomez Rueda, M.D., Rosa Inés Barañao, Ph.D. Fertility and Sterility Volume 82, Pages 1101-1105 (October 2004) DOI: 10.1016/j.fertnstert.2004.03.036 Copyright © 2004 American Society for Reproductive Medicine Terms and Conditions

FIGURE 1 Number of antral and luteinized follicles in four groups. The data represent the mean ±SD. Red column = control group; blue column = hyperstimulated group; green column = VEGF-treated group; yellow column = VEGF-treated and hyperstimulated group. *P<.005 vs. C; **P<.05 vs. C; ***P<.05 vs. HS; ****P<.01 vs. C; *****P=.028 vs. C. Fertility and Sterility 2004 82, 1101-1105DOI: (10.1016/j.fertnstert.2004.03.036) Copyright © 2004 American Society for Reproductive Medicine Terms and Conditions

FIGURE 2 Number of vessels in the four groups. The data represent the mean ±SD. Red column = control group; blue column = hyperstimulated group; green column = VEGF-treated group; yellow column = VEGF-treated and hyperstimulated group. *P<.05 vs. C; **P<.01 vs. C. Fertility and Sterility 2004 82, 1101-1105DOI: (10.1016/j.fertnstert.2004.03.036) Copyright © 2004 American Society for Reproductive Medicine Terms and Conditions

FIGURE 3 Percentage of cells with Bcl-2 expression. The data represent the mean ±SD. Red column = control group; blue column = hyperstimulated group; green column = VEGF-treated group; yellow column = VEGF-treated and hyperstimulated group. *P<.05 vs. C; **P<.05 vs. C. Fertility and Sterility 2004 82, 1101-1105DOI: (10.1016/j.fertnstert.2004.03.036) Copyright © 2004 American Society for Reproductive Medicine Terms and Conditions