The Podocyte Under Stress: AKT2 to the Rescue

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Presentation transcript:

The Podocyte Under Stress: AKT2 to the Rescue Sundararaman Swaminathan, MD, Mitchell H. Rosner, MD American Journal of Kidney Diseases Volume 63, Issue 4, Pages 555-557 (April 2014) DOI: 10.1053/j.ajkd.2014.01.008 Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 The AKT2 pathway is induced by mTORC2 under conditions of podocyte stress such as that seen in clinical conditions associated with nephron loss. When activated, AKT2 acts to protect the podocyte through inhibition of apoptosis, as well as through downregulation of RAC1, which otherwise would lead to podocyte foot-process effacement. American Journal of Kidney Diseases 2014 63, 555-557DOI: (10.1053/j.ajkd.2014.01.008) Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions