Indermeet Kohli, PhD, Rubina Shafi, PhD, Prescilia Isedeh, MD, James L

Slides:

Advertisements

Similar presentations

Topically applied ascorbic acid solution for the treatment of basal cell carcinoma (BCC) Péter Holló, MD, PhD, Hajnalka Jókai, MD, PhD, Judit Hársing,

Advertisements

Indermeet Kohli, PhD, Rubina Shafi, PhD, Prescilia Isedeh, MD, James L

Use of the diagonal mattress suture to prevent dog-ear formation

Grover disease with a contagious twist

Jing-Yi Lin, MDa,. , M. Angelica Selim, MDa, Christopher R. Shea, MDb,

Deon Wolpowitz, MD, PhD, Barbara A. Gilchrest, MD

A 52-year-old man with bullous pemphigoid and bullous cystitis

Systematized linear porokeratosis: A rare variant of diffuse porokeratosis with good response to systemic acitretin Jin-Bon Hong, MD, Cheng-Hsiang Hsiao,

A girl with a solitary red bulla

A randomized controlled crossover trial: Lidocaine injected at a 90-degree angle causes less pain than lidocaine injected at a 45-degree angle Kathryn.

Yul W. Yang, MD, PhD, David J. DiCaudo, MD

The protective effect of sunscreens, vitamin E 6% cream, and betamethasone 0.1% cream on solar-simulating radiation-induced erythema and neutrophil influx

Image registration of sequential transparent photographs to localize and detect new versus recurrent tumors in dermatologic and Mohs micrographic surgery

Josh Wharton, MD, David Roffwarg, BS, Jeremiah Miller, MD, Daniel J

Megan Wood, MD, Tom Raisanen, MD, Ingrid Polcari, MD

Expression of PD-L1 in mastocytosis

Varicella-zoster virus vaccination–induced granulomatous dermatitis

Hypertrichosis around a leg ulcer being treated with prostaglandin E1 ointment Tetsuya Honda, MD, PhD, Satoshi Koreeda, MD, PhD, Yoshiki Miyachi, MD,

Rajiv I. Nijhawan, BS, Shalu S

Primary thyroid marginal zone B-cell lymphoma in a patient with psoriatic arthritis treated with etanercept Hyunju Jin, MD, Hyun-Ho Cho, MD, Won-Jeong.

Ben Tallon, MBChB, Elizabeth Blanchard, MD, Lynne J. Goldberg, MD

Synchronous Paget disease of the breast and axilla

Rapid deterioration in a patient with primary aggressive cutaneous epidermotropic CD8+ cytotoxic T-cell (‘Berti’) lymphoma after administration of adalimumab

Decrease of ultraviolet A light–induced “common deletion” in healthy volunteers after oral Polypodium leucotomos extract supplement in a randomized clinical.

Photo-induced erythema multiforme associated with vandetanib administration Dolores Caro-Gutiérrez, MD, Maria Uxúa Floristán Muruzábal, MD, Enrique Gómez.

Chemoprevention of nonmelanoma skin cancer

A pilot trial of treprostinil for the treatment and prevention of digital ulcers in patients with systemic sclerosis Lorinda Chung, MD, David Fiorentino,

Oral green tea catechins do not provide photoprotection from direct DNA damage induced by higher dose solar simulated radiation: A randomized controlled.

David M. Lemchak, DO, Oleg E. Akilov, MD, PhD

Craig A. Elmets, Johnathan J. Ledet, Mohammad Athar

Plasma β-endorphin levels in frequent and infrequent tanners before and after ultraviolet and non-ultraviolet stimuli Mandeep Kaur, MD, Anthony Liguori,

The Vitiligo Extent Score (VES) and the VESplus are responsive instruments to assess global and regional treatment response in patients with vitiligo

Myiasis in a giant squamous cell carcinoma

Alopecia areata Journal of the American Academy of Dermatology

Treatment with 5-Fluorouracil and Celecoxib Displays Synergistic Regression of Ultraviolet Light B-Induced Skin Tumors Traci A. Wilgus, Thomas S. Breza,

Solitary mastocytoma in an adult with an unusual clinical presentation

Airway smooth muscle remodeling is a dynamic process in severe long-standing asthma Muhannad Hassan, MD, Taisuke Jo, MD, PhD, Paul-André Risse, PhD,

Infectious rash after riding elephants

Gwanghyun Jo, MD, Je-Ho Mun, MD, PhD

Rapid onset of CD8+ aggressive T-cell lymphoma during bexarotene therapy in a patient with Sézary syndrome Alexander Kreuter, MD, Peter Altmeyer, MD

The merits of adding toluidine blue–stained slides in Mohs surgery in the treatment of a microcystic adnexal carcinoma Steven Q. Wang, MD, Leonard H.

Lip edema Journal of the American Academy of Dermatology

Linear IgA disease limited to the oral mucosa

Solomon Shockman, MD, Lauren Krug, MD, Nektarios Lountzis, MD

Intense pulsed light irradiation may reverse activator protein-1 expression induced by ultraviolet B light Gwo-Shing Chen, MD, PhD, Hui-Chuan Lin, MS,

Role of p38 MAPK in UVB-Induced Inflammatory Responses in the Skin of SKH-1 Hairless Mice Arianna L. Kim, Jeffrey M. Labasi, Yucui Zhu, Xiuwei Tang,

Airway smooth muscle remodeling is a dynamic process in severe long-standing asthma Muhannad Hassan, MD, Taisuke Jo, MD, PhD, Paul-André Risse, PhD,

Bassel H. Mahmoud, Eduardo Ruvolo, Camile L

Tej Pratap Singh, Gerlinde Mayer, Peter Wolf

Narrow-Band UVB Induces More Carcinogenic Skin Tumors than Broad-Band UVB through the Formation of Cyclobutane Pyrimidine Dimer Makoto Kunisada, Hiroshi.

Ex vivo confocal microscopy of basal cell carcinoma on a 3-color scale

Medicaid acceptance among pediatric dermatologists

Jules B. Lipoff, MD, Neha Jariwala, BS, Monica Paz, MD, Rudolf R

Identification of novel targetable mutations in metastatic anorectal melanoma by next- generation sequencing Emily D. Cai, BA, Jinah Kim, MD, PhD JAAD.

Yu-Chen Huang, MD, Ying-Chih Cheng, MD

Selective Cyclooxygenase-2 Inhibition Produces Heterogeneous Erythema Response to Ultraviolet Irradiation Cristina Rodriguez-Burford, John H. Tu, MaryGail.

Jose Fernández-Vozmediano, PhD, Jose Armario-Hita, MD

Minimal improvements in the global burden of skin disease from 1990 to 2013 Jessica Mounessa, Taylor Braunberger, MD, Cory A. Dunnick, MD, Robert P. Dellavalle,

Eyebrow transplantation: Alternative body sites as a donor source

Gaps in pain management in dermatology: A needs assessment from Canada

A grayscale photograph with high dynamic range taken under a Wood's lamp for better recognition of vitiligo lesions Jung Min Bae, MD, PhD, Tae Young.

Numerous hyperpigmented macules of the oral mucosa

Acanthosis nigricans in a patient with sarcoma of unknown origin

Deede Y. Liu, MD, Muhammad I. Gul, BS, Jo Wick, PhD, Anand N

Chieko Sadahira, MD, Kozo Yoneda, MD, PhD, Yasuo Kubota, MD, PhD

“Boot foot” with pseudomonas colonization

Topically applied ascorbic acid solution for the treatment of basal cell carcinoma (BCC) Péter Holló, MD, PhD, Hajnalka Jókai, MD, PhD, Judit Hársing,

Anastasia O. Kurta, DO, Daisy Dai, PhD, Eric S

Stuart M. Goldsmith, MD, Armand B. Cognetta, MD

Resolution of endothelial activation and down-regulation of Tie2 receptor in psoriatic skin after infliximab therapy Trevor Markham, MD, Ronan Mullan,

Presentation transcript:

The impact of oral Polypodium leucotomos extract on ultraviolet B response: A human clinical study Indermeet Kohli, PhD, Rubina Shafi, PhD, Prescilia Isedeh, MD, James L. Griffith, MD, Mohammed S. Al-Jamal, MD, Narumol Silpa- archa, MD, Bradford Jackson, PhD, Mohammed Athar, PhD, Nikiforos Kollias, PhD, Craig A. Elmets, MD, Henry W. Lim, MD, Iltefat H. Hamzavi, MD Journal of the American Academy of Dermatology Volume 77, Issue 1, Pages 33-41.e1 (July 2017) DOI: 10.1016/j.jaad.2017.01.044 Copyright © 2017 Terms and Conditions

Fig 1 Ultraviolet B response. Pre-Polypodium leucotomos extract (PLE) minimal erythema dose (MED) site 1 (left) and post-PLE MED site 2 (right); set of representative clinical photographs demonstrating an increase in MED for a subject from 100 mJ/cm2 pre-PLE to 150 mJ/cm2 post-PLE administration. Journal of the American Academy of Dermatology 2017 77, 33-41.e1DOI: (10.1016/j.jaad.2017.01.044) Copyright © 2017 Terms and Conditions

Fig 2 Ultraviolet B response. Average erythema investigator global assessment (IGA) scores. Mean ± SE of the mean. Asterisk, Statistically significant change (P < .05). PLE, Polypodium leucotomos extract. Journal of the American Academy of Dermatology 2017 77, 33-41.e1DOI: (10.1016/j.jaad.2017.01.044) Copyright © 2017 Terms and Conditions

Fig 3 Ultraviolet (UV)B response. A, Average pre- and post-Polypodium leucotomos extract (PLE) relative erythema intensity. Mean ± SE of the mean. Asterisk, Statistically significant change (P < .05). B, Pre-PLE minimal erythema dose (MED) site 2, 150 mJ/cm2 (left), post-PLE MED site 2, 150 mJ/cm2 (right); set of representative clinical photographs demonstrating the decrease in erythema intensity although no change in MED. C, Pre- and post-PLE relative erythema intensity as a function of UVB dose for 1 subject. Mean ± SD. The pre-PLE MED for this subject was 100 (linear range 50–280 mJ/cm2) and post-PLE MED was 150 (linear range 75-420 mJ/cm2). Although all data points have been shown in the graph, slopes were calculated corresponding to the linear section only. D, Average pre- and post-PLE relative erythema intensity for all subjects as a function of UVB doses. Mean ± SE of the mean. Journal of the American Academy of Dermatology 2017 77, 33-41.e1DOI: (10.1016/j.jaad.2017.01.044) Copyright © 2017 Terms and Conditions

Fig 4 Ultraviolet (UV)B response. Changes in biomarkers of UV radiation exposure before and after Polypodium leucotomos extract (PLE). A, Stained nuclei for cyclobutane pyrimidine dimers (CPD), Ki67, proliferating cell nuclear antigen (PCNA), and cyclin D1. B, Sunburn cells and cytoplasmic staining for cyclooxygenase-2 (COX-2). Representative photomicrographs. (Original magnifications: ×20.) Journal of the American Academy of Dermatology 2017 77, 33-41.e1DOI: (10.1016/j.jaad.2017.01.044) Copyright © 2017 Terms and Conditions