Volume 58, Issue 5, Pages (November 2000)

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Presentation transcript:

Volume 58, Issue 5, Pages 2129-2137 (November 2000) Glomerular permselectivity in early stages of overt diabetic nephropathy Steen Andersen, Kristina Blouch, Joan Bialek, Marja Deckert, Hans-Henrik Parving, Bryan D. Myers Kidney International Volume 58, Issue 5, Pages 2129-2137 (November 2000) DOI: 10.1111/j.1523-1755.2000.00386.x Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 1 Design of the crossover study. Subjects were randomized to 60 days of either placebo (protocol 1) or losartan therapy (protocol 2). This was followed by a 15-day washout period after which each subject crossed over to 60 days of the remaining therapy not given on the first occasion. *Days on which differential solute clearances were performed. Kidney International 2000 58, 2129-2137DOI: (10.1111/j.1523-1755.2000.00386.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 2 Sieving coefficients (θ) of Ficoll are plotted as a function of Einstein-Stokes radius (ESR). Symbols are: (○) placebo-treated diabetic nephropathy; (▵) controls; *P < 0.05. Kidney International 2000 58, 2129-2137DOI: (10.1111/j.1523-1755.2000.00386.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 3 Sieving coefficients (θ) of Ficoll in diabetic nephropathy (DN) are plotted as a function of Einstein-Stokes radius (ESR). Symbols are: (○) placebo treatment; (X) losartan treatment. (Δ) P = 0.06. Data are mean ± SEM. Kidney International 2000 58, 2129-2137DOI: (10.1111/j.1523-1755.2000.00386.x) Copyright © 2000 International Society of Nephrology Terms and Conditions