Higher Risk of Cytomegalovirus and Aspergillus Infections in Recipients of T Cell– Depleted Unrelated Bone Marrow: Analysis of Infectious Complications.

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Presentation transcript:

Higher Risk of Cytomegalovirus and Aspergillus Infections in Recipients of T Cell– Depleted Unrelated Bone Marrow: Analysis of Infectious Complications in Patients Treated with T Cell Depletion Versus Immunosuppressive Therapy to Prevent Graft- versus-Host Disease Jo-Anne H. van Burik, Shelly L. Carter, Alison G. Freifeld, Kevin P. High, Kamar T. Godder, Genovefa A. Papanicolaou, Adam M. Mendizabal, John E. Wagner, Saul Yanovich, Nancy A. Kernan Biology of Blood and Marrow Transplantation Volume 13, Issue 12, Pages 1487-1498 (December 2007) DOI: 10.1016/j.bbmt.2007.08.049 Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Serious infections. A, Time to developing a serious infection (severe, life-threatening, or fatal) was similar in the 2 treatment arms over the 3-year follow-up period (P = .14). B, Survival by treatment and presence of a serious bacterial infection (P = not significant). C, Probability of developing a serious bacterial bloodstream infection (severe, life-threatening, or fatal) in the first year posttransplantation was similar in the 2 treatment arms (P = .13). Biology of Blood and Marrow Transplantation 2007 13, 1487-1498DOI: (10.1016/j.bbmt.2007.08.049) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 CMV. A, The probability of developing a serious CMV infection (severe, life-threatening, or fatal) was higher in the TCD arm (28%) compared with the M/C arm (17%) (P = .02). B, Three-year survival in patients who developed a serious CMV infection was 26% in the TCD arm versus 43% in the M/C arm (P = .09). C, Among CMV-seropositive recipients, the likelihood of developing a serious CMV infection was higher in the TCD arm (0.53) compared with the M/C arm (0.33) (P = .04). Biology of Blood and Marrow Transplantation 2007 13, 1487-1498DOI: (10.1016/j.bbmt.2007.08.049) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Aspergillosis. A, Survival by treatment and presence of a serious fungal infection. B, The likelihood of developing aspergillosis (life-threatening or fatal) by 3 years posttransplantation was greater in the TCD arm (0.16) compared with the M/C arm (0.07) (P < .01). Biology of Blood and Marrow Transplantation 2007 13, 1487-1498DOI: (10.1016/j.bbmt.2007.08.049) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions