Epicutaneous application of house dust mite induces thymic stromal lymphopoietin in nonlesional skin of patients with atopic dermatitis Janneke Landheer,

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Presentation transcript:

Epicutaneous application of house dust mite induces thymic stromal lymphopoietin in nonlesional skin of patients with atopic dermatitis Janneke Landheer, MD, Barbara Giovannone, PhD, Jeanine D. Mattson, MA, Sandra Tjabringa, PhD, Carla A.F.M. Bruijnzeel-Koomen, MD, PhD, Terrill McClanahan, PhD, Rene de Waal Malefyt, PhD, Edward Knol, PhD, DirkJan Hijnen, MD, PhD Journal of Allergy and Clinical Immunology Volume 132, Issue 5, Pages 1252-1254 (November 2013) DOI: 10.1016/j.jaci.2013.07.051 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Increased TSLP and TARC expression after epicutaneous application of HDM on nonlesional AD skin. TSLP (A) and TARC (B) gene expression in nonlesional, lesional, and APT skin (n = 5). Symbols represent patients summarized in Table I. C, TSLP immunohistochemistry in nonlesional (−) skin, lesional (+++) skin, and 24-hour APT skin (+), and 48-hour APT skin (++) with HDM. Scale bars represent 100 μm. Journal of Allergy and Clinical Immunology 2013 132, 1252-1254DOI: (10.1016/j.jaci.2013.07.051) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions