Hypoxia decreases lipogenesis via mTORC1 signalling in lymphocytes

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Hypoxia decreases lipogenesis via mTORC1 signalling in lymphocytes Hypoxia decreases lipogenesis via mTORC1 signalling in lymphocytes (A) A schematic model showing the signalling of lipogenesis. Srebp1c controls expressions of lipogenesis genes, such as Acc1 and Fasn, downstream of mTORC1 signalling. (B–D) Real-time PCR results showed that mRNA levels of lipogenesis genes, including Srebp1c (B), Acc1 (C) and Fasn (D) were decreased in hypoxia. TSC1 knockdown increases these gene expressions in both normoxia and hypoxia. Results are averages of three independent experiments. Data represent mean ± S.E.M.; *P<0.05 and **P<0.01. Geng Yin et al. Biosci. Rep. 2017;37:BSR20160479 ©2017 by Portland Press Ltd