Lymphocytes in Peyer patches regulate clinical tolerance in a murine model of food allergy Christophe P. Frossard, MS, Laurence Tropia, Conrad Hauser,

Slides:

Advertisements

Similar presentations

Dual effects of vitamin D–induced alteration of TH1/TH2 cytokine expression Victor Matheu, MD, Ove Bäck, MD, PhD, Emma Mondoc, BSc, Shohreh Issazadeh-Navikas,

Advertisements

Induction of systemic immunologic tolerance to β-lactoglobulin by oral administration of a whey protein hydrolysate Rodolphe Fritsché, PhD, Jean Jacques.

Journal of Allergy and Clinical Immunology

Regulation of TH2 responses by the pulmonary Clara cell secretory 10-kd protein Chih-Hsing Hung, MD, Li-Chen Chen, MD, Zhongjian Zhang, PhD, Bhabadeb.

High-titer IgE antibody specific for pollen allergens in northern California is associated with both wheezing and total serum IgE Elizabeth A. Erwin,

IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signaling Clinton B. Mathias, PhD, Suejy.

Christophe P Frossard, MS, Conrad Hauser, MD, Philippe A Eigenmann, MD

The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF- like (BATF), regulates lymphocyte- and mast cell–driven immune.

The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF- like (BATF), regulates lymphocyte- and mast cell–driven immune.

Designing hypoallergenic derivatives for allergy treatment by means of in silico mutation and screening Theresa Thalhamer, PhD, Heidi Dobias, MSc, Tatjana.

Differential cytokine induction by the human skin–associated autoallergen thioredoxin in sensitized patients with atopic dermatitis and healthy control.

Allergy prevention starts before conception: Maternofetal transfer of tolerance protects against the development of asthma Tobias Polte, PhD, Christian.

Ting-ting Zhang, MSc, Klaus Okkenhaug, PhD, Baher F

Frank Kirstein, PhD, Natalie E

Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis Lisa M. Bartnikas, MD, Michael F. Gurish,

Matthew C. Tunis, BSc, Wojciech Dawicki, PhD, Kaitlyn R

IL-33 dysregulates regulatory T cells and impairs established immunologic tolerance in the lungs Chien-Chang Chen, PhD, Takao Kobayashi, PhD, Koji Iijima,

CD1d restricted natural killer T cells are not required for allergic skin inflammation Abdallah Elkhal, PhD, Muriel Pichavant, PhD, Rui He, PhD, Jordan.

Is 9 more than 2 also in allergic airway inflammation?

A randomized, double-blind, placebo-controlled study of omalizumab combined with oral immunotherapy for the treatment of cow's milk allergy Robert A.

Thomas F. Tedder, PhD, Takashi Matsushita, MD, PhD

Rosaura Casas, MSc, Malin F

Histamine in the immune regulation of allergic inflammation

Suppression of antigen-specific T- and B-cell responses by intranasal or oral administration of recombinant Bet v 1, the major birch pollen allergen,

Forkhead box protein 3 demethylation is associated with tolerance induction in peanut- induced intestinal allergy Meiqin Wang, MD, PhD, Ivana V. Yang,

Differential roles for the IL-9/IL-9 receptor α-chain pathway in systemic and oral antigen–induced anaphylaxis Heather Osterfeld, BSc, Richard Ahrens,

Oliver T. Burton, PhD, Jaciel M. Tamayo, PhD, Amanda J

Frank Kirstein, PhD, Natalie E

Specific epicutaneous immunotherapy prevents sensitization to new allergens in a murine model Lucie Mondoulet, PhD, Vincent Dioszeghy, PhD, Emilie Puteaux,

Ellen Mueller Fox, PhD, Marina N

Dendritic cells modulated by cytokine-expressing adenoviruses alleviate eosinophilia and airway hyperresponsiveness in an animal model of asthma Yi-Ling.

Takao Kobayashi, PhD, Koji Iijima, PhD, Alexander L

Food Allergy Herbal Formula-2 silences peanut-induced anaphylaxis for a prolonged posttreatment period via IFN-γ–producing CD8+ T cells Kamal D. Srivastava,

A fusion protein of flagellin and ovalbumin suppresses the TH2 response and prevents murine intestinal allergy Stefan Schülke, PhD, Manja Burggraf, MSc,

Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13 Rui He, MD, PhD, Hye Young Kim,

Regulation of allergic airway inflammation by class I–restricted allergen presentation and CD8 T-cell infiltration James W. Wells, PhD, Christopher J.

Serum IgE response to orally ingested antigen: A novel IgE response model with allergen-specific T-cell receptor transgenic mice Kan Shida a,b, Satoshi.

Iván López-Expósito, PhD, Ying Song, MD, Kirsi M

Prophylactic and therapeutic inhibition of allergic airway inflammation by probiotic Escherichia coli O83 Christian Zwicker, MSc, Priya Sarate, MSc,

IgE-class–specific immunosuppression in offspring by administration of anti-IgE to pregnant mice Hideaki Morita, MD, PhD, Masato Tamari, MD, PhD, Masako.

Mechanisms underlying differential food allergy response to heated egg

Role of B cells in TH cell responses in a mouse model of asthma

Induction of long-lived allergen-specific plasma cells by mucosal allergen challenge Elke O. Luger, PhD, Verena Fokuhl, MSc, Michael Wegmann, PhD, Melanie.

Early decreases in blood eosinophil levels with reslizumab

Antigen-primed splenic CD8+ T cells impede the development of oral antigen–induced allergic diarrhea Akiko Yamada, MD, Yusei Ohshima, MD, PhD, Motoko.

Mukesh Kumar, PhDa, Aruna K. Behera, PhDa, Jianan Hu, MDa, Richard F

The Editors’ Choice Journal of Allergy and Clinical Immunology

Effects of established allergen sensitization on immune and airway responses after secondary allergen sensitization Katharina Blumchen, MD, Kerstin Gerhold,

Induction of systemic immunologic tolerance to β-lactoglobulin by oral administration of a whey protein hydrolysate Rodolphe Fritsché, PhD, Jean Jacques.

IL-12 affects Dermatophagoides farinae–induced IL-4 production by T cells from pediatric patients with mite-sensitive asthma Takeshi Noma, MD, PhD, Izumi.

Genetic susceptibility to food allergy is linked to differential TH2-TH1 responses in C3H/HeJ and BALB/c mice Vivian Morafo, PhD*, Kamal Srivastava,

TH1-promoting DNA immunization against allergens modulates the ratio of IgG1/IgG2a but does not affect the anaphylactic potential of IgG1 antibodies

Antigen-specific and nonspecific determinants of cytokine production during topical sensitization of mice to chemical allergens Artin Moussavi, PhDa,

Ellen Mueller Fox, PhD, Marina N

Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand, thymic stromal lymphopoietin, and IL-33 Amit K. Mehta,

The steroidogenic enzyme Cyp11a1 is essential for development of peanut-induced intestinal anaphylaxis Meiqin Wang, MD, PhD, Julita Ramirez, DVM, PhD,

Antigen coupled with Lewis-x trisaccharides elicits potent immune responses in mice Shih-Chang Hsu, BS, Tsung-Hsien Tsai, MD, Hirokazu Kawasaki, PhD,

Qianli Zhuang, MD, PhD, Bruce Mazer, MD

DNA methylation of TH1/TH2 cytokine genes affects sensitization and progress of experimental asthma Stephanie Brand, PhD, Dörthe Andrea Kesper, PhD,

Rodrigo Jiménez-Saiz, PhD, Derek K. Chu, MD, PhD, Talveer S

In vivo effects of glucocorticoids on IgE production

Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma

Heat denaturation affects the ProDer p 1 IgE reactivity and downregulates the development of the specific allergic response Mauro Magi, MD, Lida Garcia,

Ovalbumin-specific IgE modulates ovalbumin-specific T-cell response after repetitive oral antigen administration Nemuko Omata, MD, Yusei Ohshima, MD,

Innate immune defects correlate with failure of antibody responses to H1N1/09 vaccine in HIV-infected patients Suresh Pallikkuth, PhD, Sudheesh Pilakka.

M cell targeting with Aleuria aurantia lectin as a novel approach for oral allergen immunotherapy Franziska Roth-Walter, PhD, Isabella Schöll, PhD, Eva.

Epicutaneous immunization with ovalbumin and CpG induces TH1/TH17 cytokines, which regulate IgE and IgG2a production Monika Majewska-Szczepanik, PhD,

Placental transfer of allergen-specific IgG but not IgE from a specific immunotherapy– treated mother Sabine Flicker, PhD, Katharina Marth, MD, Heinz.

Janet Chou, MD, Maxim Lutskiy, MD, PhD, Erdyni Tsitsikov, PhD, Luigi D

TNF can contribute to multiple features of ovalbumin-induced allergic inflammation of the airways in mice Susumu Nakae, PhD, Carolina Lunderius, PhD,

Presentation transcript:

Lymphocytes in Peyer patches regulate clinical tolerance in a murine model of food allergy Christophe P. Frossard, MS, Laurence Tropia, Conrad Hauser, MD, Philippe A. Eigenmann, MD Journal of Allergy and Clinical Immunology Volume 113, Issue 5, Pages 958-964 (May 2004) DOI: 10.1016/j.jaci.2003.12.017

Fig 1 β-Lactoglobulin–specific serum IgG1 (A), IgG2a (C), and IgE (E) antibody titers by ELISA. Numbers of BLG-specific IgG1 (B) and IgG2a (D) antibody-producing cells counted by ELISPOT in spleen or in Peyer patches. Results are pooled from at least 3 different experiences. ND, Not detectable. ∗∗P<.001, SENS (mice sensitized with β-lactoglobulin) vs CTX; ∗P<.05, TOL (mice tolerized with β-lactoglobulin) vs CTX; +P<.05, TOL vs SENS in SC; otherwise P=not significant. Journal of Allergy and Clinical Immunology 2004 113, 958-964DOI: (10.1016/j.jaci.2003.12.017)

Fig 2 Antigen-activated MNC (A) or PPC (B) proliferation. CD3+ cells were isolated from CTX mice and activated with BLG (CTXBLG) or OVO (CTXOVO), BLG or OVO-activated cells from TOL mice (mice tolerized with β-lactoglobulin) (TOLBLG and TOLOVO), or BLG or OVO-activated cells from SENS mice (mice sensitized with β-lactoglobulin) (SENSBLG and SENSOVO). Results shown are from pooled cells in one representative experiment. Journal of Allergy and Clinical Immunology 2004 113, 958-964DOI: (10.1016/j.jaci.2003.12.017)

Fig 3 Numbers of unstimulated and BLG-specific IFN-g (A and B), IL-4 (C and D), and IL-10 (E and F) producing cells counted by ELISPOT. Results are pooled from 3 different experiments. *P<.05, TOL (mice tolerized with β-lactoglobulin) vs SENS (mice sensitized with β-lactoglobulin); **P<.05, SENS vs CTX; +P<.05, TOL vs CTX; otherwise P=not significant. Journal of Allergy and Clinical Immunology 2004 113, 958-964DOI: (10.1016/j.jaci.2003.12.017)

Fig 4 Naive mice (nontol) or mice previously orally tolerized to BLG (pretol) were subsequently sensitized (ip) with BLG adsorbed to alumn. BLG-specific serum IgG1 (A), IgG2a (B), and IgE (C) antibody titers from pretol and nontol mice. Antigen-activated proliferation of cells from pooled SC (D) or MNC (E). ∗P<.05, nontol vs pretol. Journal of Allergy and Clinical Immunology 2004 113, 958-964DOI: (10.1016/j.jaci.2003.12.017)

Fig 5 β-Lactoglobulin–specific serum IgG1 antibody titers after adoptive transfer of MNC (A) or PPC (C). Numbers of IgG1 antibody-secreting cells counted by ELISPOT in SC or PP after adoptive transfer of MNC (B) or PPC (D). Results are pooled data from two different experiments. ∗P<.01, SENS (mice sensitized with β-lactoglobulin) vs TOL (mice tolerized with β-lactoglobulin); ∗∗P<.001, SENS vs TOL. Journal of Allergy and Clinical Immunology 2004 113, 958-964DOI: (10.1016/j.jaci.2003.12.017)