Fig. 3. Increased expression of exhaustion markers and apoptosis markers on CAR8 cells in the presence of TCR antigen. Increased expression of exhaustion.

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Fig. 3. Increased expression of exhaustion markers and apoptosis markers on CAR8 cells in the presence of TCR antigen. Increased expression of exhaustion markers and apoptosis markers on CAR8 cells in the presence of TCR antigen. (A) HY-CAR4 and HY-CAR8 expansion in the bone marrow of leukemia-bearing HY+ or HY− mice (n = 5) 7 days after CAR T cell infusion. (B and C) Percent caspase 3/7+ CAR8 and CAR4 cells at 72 hours after infusion. (D and E) Mean fluorescence intensity (MFI) of PD-1 and LAG3 on HY-specific CAR T cells in male (HY+) and female (HY−) recipients day +7 after infusion (**P < 0.01, ****P < 0.0001). (F) Overlaid zebra plots of PD-1 and LAG3 expression of endogenous T cells or HY-CAR4 or HY-CAR8 cells in the presence or absence of HY antigen (one-way ANOVA performed for all comparisons). Yinmeng Yang et al., Sci Transl Med 2017;9:eaag1209 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works