Phylogenetic analysis and domain structure of CALM proteins.

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Phylogenetic analysis and domain structure of CALM proteins. Phylogenetic analysis and domain structure of CALM proteins. (A) Phylogenetic tree of predicted protein sequences for CALM orthologues across eukaryotes. Supergroups are coloured for clarity. The topology shown is the best scoring maximum likelihood topology (RaxML). The box provides a key to symbols to indicate statistical support. (B) Domain architecture of CALM proteins corresponding to taxa in A. Grey boxes show the position of the ANTH domain; the protein length in amino acids is stated on the right. A sequence identified from P. tetraurelia could not be reliably resolved and was therefore excluded. A high degree of conservation is seen in general domain architecture, although excavates encode CALM proteins that are slightly shorter than average. Paul T. Manna et al. J Cell Sci 2015;128:2130-2142 © 2015. Published by The Company of Biologists Ltd