A: Representative sections from the LV of sham and diabetic Ntg and IGF-1R mice. A: Representative sections from the LV of sham and diabetic Ntg and IGF-1R.

Slides:

Advertisements

Similar presentations

Inhibition of ILK by QLT-0267 suppresses type I and type III collagen expression and ameliorates interstitial collagen deposition and renal fibrosis after.

Advertisements

Bindiya Patel et al. BTS 2018;3:

Klotho reduction increases the expression of cytokine response factors in the CP. (A–C) ICAM1 (A and B) and IRF7 (C) immunoreactivity in the CP of 19-

Fig. 3. Features of PH in KRasLA2 transgenic mice.

PD-1 and LAG-3 expression in MSI and MSS colorectal cancer specimens.

INT-767 treatment prevents renal lipid accumulation in diabetic DBA/2J mice. INT-767 treatment prevents renal lipid accumulation in diabetic DBA/2J mice.

Prmt7 deficiency causes a fiber-type switch toward glycolytic.

Renal microvascular injury 6 months after induction of JG cell-specific Gsα knockout. Renal microvascular injury 6 months after induction of JG cell-specific.

TFE3 prevents diet‐induced obesity and metabolic syndrome

Fluorescence-stained images and respective bright-field images of mouse spleen tissue sections area investigated using Raman spectroscopy. Fluorescence-stained.

Bindiya Patel et al. BTS 2018;j.jacbts

The adipose tissue of BALB/c scid mice is quantitatively, but not qualitatively, different than that of BALB/c control mice. The adipose tissue of BALB/c.

Isaac Perea-Gil et al. BTS 2016;1:

Molecular and morphological analysis of Pitrm1+/− mouse brain

Cardiac Fibrosis at 18 Weeks Post TAC (A) Representative images (original magnification ×20) of Picrosirius red-stained cardiac tissue sections from HF +

Rescuing mGPDH deficiency improves skeletal muscle regeneration during obesity and diabetes Rescuing mGPDH deficiency improves skeletal muscle regeneration.

Impaired ECM protein synthesis in infarcted area of S100a4cre+/− × Fstl1flox/flox mice Impaired ECM protein synthesis in infarcted area of S100a4cre+/−

Anish Krishnan, BSc, Douglas Drak, BSc, Shisan Bao, PhD, David S

BDNF expression in the cerebellum and brain stem region.

Fig. 4. Features of PH in LLC1 lung tumor mice.

Renal Fibrosis and Plasma Creatinine Levels at 18 Weeks Post TAC (A) Plasma creatinine levels. (B) Representative images (original magnification ×20) of.

Distinct collagen structures in the upper and lower neonatal dermis (related to Fig 1)‏ Distinct collagen structures in the upper and lower neonatal dermis.

LV Structure, Function, and Circulating BNP Levels at 18 Weeks Post TAC (A) (B) LVEDD and LVESD (mm) throughout the experimental protocol. (C) Percent.

NRP1-expressing myeloid cells influence adipocyte hypertrophy, development of fatty liver, and CLSs. NRP1-expressing myeloid cells influence adipocyte.

ILK knockdown decreases mTOR signaling in PKD kidneys.

Sebastiano Sciarretta et al. JACC 2018;71:

Distribution of splenic T cells, B cells, and NK cells in NSG hL-7xhIL-15 humanized mice. Distribution of splenic T cells, B cells, and NK cells in NSG.

Tomoregulin-1 improves cardiac pathological changes after pressure overload. Tomoregulin-1 improves cardiac pathological changes after pressure overload.

Diabetic FXR KO kidney showed increased lipid accumulation.

INT-747 treatment showed antifibrotic, anti-inflammatory, and antioxidative effects on diabetic DBA/2J mice. INT-747 treatment showed antifibrotic, anti-inflammatory,

Cyp8b1−/− mice have improved islet insulin secretion and increased islet insulin content but unchanged β-cell mass. Cyp8b1−/− mice have improved islet.

Left: Baseline brain white and gray matter uptake rates of [18F]-FTHA (A) and [11C]-palmitate (B). Left: Baseline brain white and gray matter uptake rates.

A: Total collagen content by Sirius red staining in cardiac tissue of control (SD) animals. A: Total collagen content by Sirius red staining in cardiac.

Detection of nuclear foci by FISH on frozen sections of diaphragm muscle prepared from 2-month-old DMSXL mice. Detection of nuclear foci by FISH on frozen.

Predicted percentage of home discharge by diabetes group adjusting for all variables listed in the age-centered logistic regression model with examination.

Significant pathological changes and activation of Nrf2 pathway in the glomeruli of human diabetic nephropathy patients. Significant pathological changes.

Plaque area remained increased in the previously hyperglycemic mice.

Flow cytometry of subcutaneous adipose tissue stromovascular cells.

Fig. 3. Features of PH in KRasLA2 transgenic mice.

The clinical and histological changes of arthritis in gp130F759.

CD169+ macrophages mediate the transport of bacteria to T cell zones by trans-infecting CD8α+ DCs. CD169+ macrophages mediate the transport of bacteria.

Fragment N expression does not affect islet morphology and cellularity

Pericentrin expression in human and murine tissues.

Loss of protection by linagliptin against obesity-related inflammation and insulin resistance in MIP-1α−/− mice. Loss of protection by linagliptin against.

Effect of berberine on white adipose tissue mass.

Metformin and rapamycin decreased tumor weights in obese prediabetic mice. Metformin and rapamycin decreased tumor weights in obese prediabetic mice. A:

FFAs have differential effects on NFκB translocation and ROS generation. 3T3–L1 adipocytes differentiated in 5 or 25 mmol/l glucose were cultured on glass.

E11 pancreas cultured for 6 days in the presence of morpholine-ring antisense against GIP, GIPR, or control. E11 pancreas cultured for 6 days in the presence.

Higher levels of PEDF-impaired skin structure and function.

Disruption of MAM integrity and insulin signaling in liver of diet-induced diabetic mice. Disruption of MAM integrity and insulin signaling in liver of.

Effect of PP on AT morphology and inflammation after 3 days of treatment. Effect of PP on AT morphology and inflammation after 3 days of treatment. A:

Liver fibrosis after CCl4 injury in 5αR1-KO and WT mice.

Insulin resistance and hepatic steatosis in ASKO mice.

PEDF inhibits Wnt/T-cell factor/β-catenin signaling in resting and wounded skin. PEDF inhibits Wnt/T-cell factor/β-catenin signaling in resting and wounded.

Functional and histological examinations of diabetic EC-PKCβ2Tg and WT mice. Functional and histological examinations of diabetic EC-PKCβ2Tg and WT mice.

Urinary albumin excretion and histology of glomeruli.

Glucose-stimulated insulin secretion, plasma glucagon levels, and pancreatic hormone contents. Glucose-stimulated insulin secretion, plasma glucagon levels,

Expression of PKCδ in islets and other tissues of control and PKCδKN-overexpressing mice. Expression of PKCδ in islets and other tissues of control and.

A: Gene expression of β-myosin heavy chain (hypertrophic marker) was analyzed on real-time PCR and normalized against 18S expression. n = 8–11 for each.

Morphologic changes induced in immortalized human podocytes after treatment with TGF-β1 (10 ng/mL, right) for 3 days when compared with control cells (left),

Increased pancreatic insulin content and islet size and protection against HFD- and palmitate-induced cell death in PKCδKN-overexpressing mice. Increased.

IKKβ protects adipocytes from HFD-induced cell death.

Proprioceptive sensory neurons and muscle spindles are marked reduced in adult Swl/+ mice. Proprioceptive sensory neurons and muscle spindles are marked.

Antigen-specific CD8+ T cells express higher levels of PD-1 in animals that received the optimized SSX2 vaccine. Antigen-specific CD8+ T cells express.

Representative macrophage staining images only from the knee joints of CAIA mice injected s.c. with GalNAc–MASP-3–siRNA duplex 2 or GalNAc–luciferase–siRNA.

Ablation of Nf1 in HOXB7 lineage cells gives rise to diffuse cNF.

Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8 and Stat3+/+:HPV8 mice. Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8.

NIX loss delays cancer progression in KRAS-driven models of PDAC

N1 decoys reduced perfusion and JAG-specific decoys disrupted pericyte association in Mm5MT-FGF4 tumors. N1 decoys reduced perfusion and JAG-specific decoys.

Detection of microcalcifications in 4T1 mammary tumors and human breast tumor tissue. Detection of microcalcifications in 4T1 mammary tumors and human.

Presentation transcript:

A: Representative sections from the LV of sham and diabetic Ntg and IGF-1R mice. A: Representative sections from the LV of sham and diabetic Ntg and IGF-1R mice. Collagen deposition appears red (sirius red stain; magnification ×200). Scale bars show 40 μm. B: Quantitation of collagen area/total ventricular area pooled data. n = 8–12 in each group; *P < 0.05 vs. Ntg sham; †P < 0.05 vs. Ntg diabetic. A high-quality digital representation of this figure is available in the online issue.)‏ Karina Huynh et al. Diabetes 2010;59:1512-1520 ©2010 by American Diabetes Association