Upon challenge with oxazolone, human leukocytes (mainly consisting of T cells) infiltrate the dermis and epidermis. Upon challenge with oxazolone, human.

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Upon challenge with oxazolone, human leukocytes (mainly consisting of T cells) infiltrate the dermis and epidermis. Upon challenge with oxazolone, human leukocytes (mainly consisting of T cells) infiltrate the dermis and epidermis. (A,B) Photomicrographs of immunohistochemically stained paraffin sections of the skin: (A) stained with anti-hCD45 antibody and (B) stained with anti-CD3 antibody. Skin samples for both A and B were taken from the following mice: BALB/c mouse challenged with ethanol (a); non-engrafted NOD-scid IL2Rγnull mouse (b); BALB/c mouse challenged with oxazolone (c); and engrafted NOD-scid IL2Rγnull mouse treated with oxazolone (d). Arrows indicate invaded human leukocytes. Scale bars: 100 μm; 10 μm (insets). Thomas Nolte et al. Dis. Model. Mech. 2013;6:125-134 © 2012. Published by The Company of Biologists Ltd