Polymorphisms in MTHFR and MTRR genes associated with blood plasma homocysteine concentration and sperm counts Debbie Montjean, M.Sc., Moncef Benkhalifa,

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Polymorphisms in MTHFR and MTRR genes associated with blood plasma homocysteine concentration and sperm counts Debbie Montjean, M.Sc., Moncef Benkhalifa, Ph.D., Lionel Dessolle, M.D., Paul Cohen-Bacrie, D.Pharm., Stéphanie Belloc, D.Pharm., Jean-Pierre Siffroi, M.D., Ph.D., Célia Ravel, M.D., Ph.D., Anu Bashamboo, Ph.D., Kenneth McElreavey, Ph.D. Fertility and Sterility Volume 95, Issue 2, Pages 635-640 (February 2011) DOI: 10.1016/j.fertnstert.2010.08.054 Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Box plot showing sperm parameters according to MTHFR 665 genotype. Similar results were found for other MTHFR and MTRR genotypes. Fertility and Sterility 2011 95, 635-640DOI: (10.1016/j.fertnstert.2010.08.054) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Effect of MTHFR 665 polymorphism on plasma Hcy level and impact of Hcy level variation on sperm counts. (A) Box plot showing Hcy levels according to MTHFR 665 genotype. (B) Linear regression of sperm counts according to Hcy levels. Gray lines represent the 95% CIs of the sperm counts distribution and predictions. Hcy levels are expressed in μmol/L. Fertility and Sterility 2011 95, 635-640DOI: (10.1016/j.fertnstert.2010.08.054) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions