Clinical and immunologic variables in skin of patients with atopic eczema and either positive or negative atopy patch test reactions Elisabeth G. Langeveld-Wildschut,

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Presentation transcript:

Clinical and immunologic variables in skin of patients with atopic eczema and either positive or negative atopy patch test reactions Elisabeth G. Langeveld-Wildschut, MD, PhDa, Piet L.B. Bruijnzeel, MD, PhDb, Geert C. Mudde, PhDc, Coraline Versluisa, Adrie G. Van Ieperen-Van Dijka, Ilse C. Biharia, Edward F. Knol, PhDa, Theo Thepen, PhDa, Carla A.F.M. Bruijnzeel-Koomen, MD, PhDa, Frank C. van Reijsen, PhDa Journal of Allergy and Clinical Immunology Volume 105, Issue 5, Pages 1008-1016 (May 2000) DOI: 10.1067/mai.2000.106544 Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 1 Number of CD3+, CD25+, and EG2+ cells per square millimeter in the dermis of normal control subjects (NC) , atopic control subjects (AC) , patients with AE and negative APT reactions 0 and 24 hours after patch testing (APT- AE) , and patients with AE and positive APT reactions 0 and 24 hours after patch testing (APT+ AE) . Results are shown as mean values ± SEM of 6 different individuals per group. Journal of Allergy and Clinical Immunology 2000 105, 1008-1016DOI: (10.1067/mai.2000.106544) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 2 Number of IgE+ and unoccupied FcϵRI+ cells in epidermis (epi , per 200 basal membrane cells) and dermis (der , per square millimeter) in normal control subjects (NC) , atopic control subjects (AC) , patients with AE and negative APT reactions (APT- AE) , and patients with AE and positive APT reactions (APT+ AE) . Biopsy specimens were obtained from untreated skin. Results are shown as mean values ± SEM of 10 different individuals per group. Journal of Allergy and Clinical Immunology 2000 105, 1008-1016DOI: (10.1067/mai.2000.106544) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 3 Binding of anti-IgE in skin of patients with AE and negative APT reactions (A ) and patients with AE and positive APT reactions (B ). Biopsy specimens were obtained from untreated skin. Two representative photomicrographs are shown (objective magnification 20×). Journal of Allergy and Clinical Immunology 2000 105, 1008-1016DOI: (10.1067/mai.2000.106544) Copyright © 2000 Mosby, Inc. Terms and Conditions