CXCL10/CXCR3 overexpression in invasive mucinous adenocarcinoma (IMA).

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CXCL10/CXCR3 overexpression in invasive mucinous adenocarcinoma (IMA). CXCL10/CXCR3 overexpression in invasive mucinous adenocarcinoma (IMA). CXCL10 concentration was assessed in 70 bronchoalveolar lavage fluid (BALF) supernatants from patients by an antibody magnetic bead assay (Bioplex® System). Each sample was assessed in duplicate. a) CXCL10 concentrations in BALF supernatants from IMA (n=38), lepidic predominant lung adenocarcinoma (LPA; n=25) and controls (n=7). p-values reflect Kruskal–Wallis test or Mann–Whitney test. Data displayed as means with sem indicated by whiskers. b) Survival curve of patients with high and low CXCL10 levels in BALF supernatants (log rank test). c) CXCL10 and CXCR3 staining (brown) in IMA and LPA. d) Correlation between CXCL10 and CXCR3 staining scores (Spearman's rho test). Michaël Duruisseaux et al. ERJ Open Res 2017;3:00047-2016 ©2017 by European Respiratory Society