Pegylated and Conventional Interferon-α Induce Comparable Transcriptional Responses and Inhibition of Tumor Growth in a Human Melanoma SCID Mouse Xenotransplantation.

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Presentation transcript:

Pegylated and Conventional Interferon-α Induce Comparable Transcriptional Responses and Inhibition of Tumor Growth in a Human Melanoma SCID Mouse Xenotransplantation Model Clemens Krepler, Ulrich Certa, Volker Wacheck, Burkhard Jansen, Klaus Wolff, Hubert Pehamberger Journal of Investigative Dermatology Volume 123, Issue 4, Pages 664-669 (October 2004) DOI: 10.1111/j.0022-202X.2004.23433.x Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Human melanoma SCID mouse xenotransplantation model. (A) Tumor growth curves and treatment schedules of mice treated with 900 μg PEG-IFN-α (300 μg IFN-α equivalent) once weekly (PEG, ▪), 100 μg IFN-α three times per week (IFN, ▴) or saline buffer (SAL, ♦). Squares indicate the time points when PEG-IFN-α or IFN-α were injected. (B) Tumor, spleen, and mouse weight after 4 wk of treatment. Journal of Investigative Dermatology 2004 123, 664-669DOI: (10.1111/j.0022-202X.2004.23433.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Immunohistological analysis of human melanoma xenotransplants Ki67 proliferation assay of tumors (A, B), apoptosis in tumor biopsies assessed by TUNEL staining (C, D), saline (A, C), and PEG treated (B, D), after 4 wk of treatment, scale bars=250 μm (A, B) and 500 μm (C, D). Journal of Investigative Dermatology 2004 123, 664-669DOI: (10.1111/j.0022-202X.2004.23433.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Cluster analysis of the genes involved in tumor growth inhibition. Genes were selected based on change factors and low experimental variation and details appear in Table I. Shades of red indicate grades of up- and of blue downregulation. Expression values in the saline-treated group were used as baseline. The HSP-70 gene, the only gene induced by PEG-IFN-α (PEG) and suppressed by IFN-α (IFN) is highlighted with a hatched box marked by an arrow. Journal of Investigative Dermatology 2004 123, 664-669DOI: (10.1111/j.0022-202X.2004.23433.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions