Fig. 1 Inbred mouse strains carrying monoclonal tumors display a symmetrical yet disparate response to ICB, associated with a distinctive gene signature.

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Presentation transcript:

Fig. 1 Inbred mouse strains carrying monoclonal tumors display a symmetrical yet disparate response to ICB, associated with a distinctive gene signature. Inbred mouse strains carrying monoclonal tumors display a symmetrical yet disparate response to ICB, associated with a distinctive gene signature. (A) Representative Renca tumor growth curves showing ICB nonresponders (red), intermediate responders (orange), and responders (blue) to ICB. (B and C) Representative growth curves of mice with bilateral AB1 tumors (B) or Renca tumors (C) treated with ICB (n = 10), color-coded per mouse. (D) Experimental design. (E and F) PCA of responsive (RS) and nonresponsive (NR) AB1 tumors (E) and Renca tumors (F) (n = 12 tumors per group). (G and H) Unsupervised-hierarchical clustering of top differentially expressed genes separating responsive and nonresponsive tumors. For AB1 (G), 10,307 genes were differentially expressed in responders versus nonresponders (top 200 shown) and 127 genes for Renca (H) (all shown; also see data file S1). Rachael M. Zemek et al., Sci Transl Med 2019;11:eaav7816 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works