Prevention of vascular calcification with bisphosphonates without affecting bone mineralization: a new challenge? Ellen G. Neven, Marc E. De Broe, Patrick.

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Prevention of vascular calcification with bisphosphonates without affecting bone mineralization: a new challenge? Ellen G. Neven, Marc E. De Broe, Patrick C. D'Haese Kidney International Volume 75, Issue 6, Pages 580-582 (March 2009) DOI: 10.1038/ki.2008.663 Copyright © 2009 International Society of Nephrology Terms and Conditions

Figure 1 Potential mechanisms involved in the calcification paradox. Bisphosphonates may reduce vascular calcification indirectly by inhibiting bone resorption or directly by either physicochemical interference with hydroxyapatite crystal formation or biological interaction with vascular smooth muscle cell function in the vessel wall. LDL, low-density lipoprotein. Kidney International 2009 75, 580-582DOI: (10.1038/ki.2008.663) Copyright © 2009 International Society of Nephrology Terms and Conditions