Efficacy of BP2 in prophylaxis against biomaterial-associated S

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Efficacy of BP2 in prophylaxis against biomaterial-associated S Efficacy of BP2 in prophylaxis against biomaterial-associated S. epidermidis RP62a infection. Efficacy of BP2 in prophylaxis against biomaterial-associated S. epidermidis RP62a infection. SEpvp biomaterial segments were implanted subcutaneously in C57BL/6 mice, and BP2 (5 mg/kg) or saline was injected along the implanted segments 3 h prior to challenge with 106 CFU of S. epidermidis RP62a. Mice were sacrificed after 24 h, and numbers of CFU adherent to the implants and present in peri-implant tissue were assessed. Two-sample comparisons were made using a two-tailed Mann-Whitney rank sum test. The significance of differences between the frequencies of categorical variables was determined using Fisher's exact test. Paulus H. S. Kwakman et al. Antimicrob. Agents Chemother. 2006; doi:10.1128/AAC.00575-06