Heterogeneity of TCRβ repertoire in autoimmune diseases.

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Presentation transcript:

Heterogeneity of TCRβ repertoire in autoimmune diseases. Heterogeneity of TCRβ repertoire in autoimmune diseases. (A) Spearman correlation of Vβ gene, Jβ gene and V-J pairings between any two Subjects (Mann-Whitney test). (B) Overlapped rate (Jaccard Index) of TCRβ clone repertoire between any two Subjects (Mann-Whitney test). (C) Sample incidences of the top 50 clones for three groups. (D) Percentage of clone number in total clones are shown with the clone’s publicity. (E) Top 100 (ranking by publicity) SLE specific clones (y-axes) distributed among all SLE samples (x-axes). The red indicates the clone was observed in the sample, and the blue indicates the clone was not observed in the sample. (F) All 56 RA specific clone distributions among all RA samples. (G) Top 100 clones (ranking by publicity) distributed in HC samples. HC, healthy control; J, joining; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; TCR, T cell receptor; V, variable. Xiao Liu et al. Ann Rheum Dis 2019;78:1070-1078 ©2019 by BMJ Publishing Group Ltd and European League Against Rheumatism