(Top) Micrographs of SNAIL-HA and mock-infected cells.

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(Top) Micrographs of SNAIL-HA and mock-infected cells. (Top) Micrographs of SNAIL-HA and mock-infected cells. Arrows indicate the phenotypic change induced by SNAIL. Bar = 50 μm. (Bottom) Immunostaining of ectopic SNAIL expression using an antibody to HA. Bar = 10 μm. (Left) Normalized SNAIL. Vitamin D receptor (VDR) and E-cadherin mRNA levels were measured by real-time reverse transcriptase–PCR. (Right) Protein expression was estimated by Western blot. Numbers refer to fold increase over untreated mock-infected cells. SNAIL inhibits the induction of L1-NCAM and filamin by 1,25(OH)D2D3. Wild-type (left) but not mutant (right) SNAIL proteins inhibit VDR transcriptional activity (4XVDRE-tk-luciferase). Reprinted from reference (50), with permission. Michael F. Holick CJASN 2008;3:1548-1554 ©2008 by American Society of Nephrology