Results from the ROI-restricted TBSS group analysis for the right dorsal cingulum. Results from the ROI-restricted TBSS group analysis for the right dorsal.

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Results from the ROI-restricted TBSS group analysis for the right dorsal cingulum. Results from the ROI-restricted TBSS group analysis for the right dorsal cingulum. A, ROI-restricted TBSS analysis revealed a significant decrease in FA in adolescents with IBS compared to non-IBS cohort (IBS patients < healthy controls; p < 0.05, TFCE corrected; color bar is scaled from 0.95 to 1) for a cluster located in the right dorsal cingulum. TFCE-corrected map overlaid onto MNI 152 T1 1-mm brain and thresholded (0.2) mean FA skeleton (green) template in FSLView (version 3.2.0) with superimposed JHU binary mask for the right dorsal cingulum shown in pink. To improve visualization, FSL’s tbss-fill command was used to thicken tracts that showed significant group differences in FA. MNI coordinates for the peak voxel in the FA cluster are x = 8.83, y = 3.5, z = 33.6. Images are displayed in radiologic orientation. B, Bar graph showing mean values extracted from significant FA cluster in IBS patients and healthy controls, F(1,28) = 12.22, p = 0.002. Asterisk denotes significant group differences with IBS patients showing decreased FA compared to healthy controls. Catherine S. Hubbard et al. eNeuro 2018;5:ENEURO.0354-17.2018 ©2018 by Society for Neuroscience