Fig. 6 IT1t controls induced and spontaneous inflammation in vitro in cells from patients with SLE. IT1t controls induced and spontaneous inflammation.

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Fig. 6 IT1t controls induced and spontaneous inflammation in vitro in cells from patients with SLE. IT1t controls induced and spontaneous inflammation in vitro in cells from patients with SLE. (A) PBMCs from healthy controls (HC) and patients with lupus (P) were stimulated with R848 to recapitulate disease flares and treated or not with IT1t (20 μM). Effect of IT1t was evaluated by IFN-α dosage in cell supernatants by digital ELISA (Simoa) or by intracellular IFN-α expression by flow cytometry. (B) Effect of IT1t on IFN-α secretion from TLR7-stimulated cells from patients (P3, P4, P5, and P6) was measured by Simoa. Box and whisker plots with median ± SEM showing minimum to maximum. Friedman test with Dunnett post hoc correction. (C) Intracellular IFN-α expression was assessed by flow cytometry and (D) IFN-α was dosed in the supernatant of cells from P1 stimulated with R848 (5 μg/ml) and treated with IT1t. (E) Effect of IT1t on cells from patients with spontaneous inflammation (SpI) juvenile SLE (JSLE) was evaluated on IFN-α production by (F) Simoa in the cell supernatant, by flow cytometry to measure pSTAT1 (G and H) and pSTAT3 (I and J), and by RT-qPCR (K) to quantify mRNA levels in PBMCs from four different patients with JSLE. (H and J) Friedman test. ***P < 0.001, **P < 0.01, *P < 0.05. NS, nonstimulated. Nikaïa Smith et al. Sci Adv 2019;5:eaav9019 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).