Critical cerebral perfusion pressure during tepid heart operations in dogs Walter Plöchl, MD, David J. Cook, MD, Thomas A. Orszulak, MD, Richard C. Daly,

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Critical cerebral perfusion pressure during tepid heart operations in dogs Walter Plöchl, MD, David J. Cook, MD, Thomas A. Orszulak, MD, Richard C. Daly, MD The Annals of Thoracic Surgery Volume 66, Issue 1, Pages 118-123 (July 1998) DOI: 10.1016/S0003-4975(98)00355-5

Fig 1 Cerebral blood flow (CBF) (mL · 100 g−1 · min−1) versus mean arterial blood pressure (MAP). Values are mean ± standard deviation. Regression curves for CBF were generated from individual CBF values for MAPs from 35 to 50 mm Hg and for MAPs from 60 to 70 mm Hg. The curve consists of a pressure-independent flat portion for MAPs greater than or equal to 60 mm Hg and a pressure-dependent steep portion for MAPs less than or equal to 50 mm Hg. (∗p < 0.05 versus MAP of 60 mm Hg by repeated-measures analysis of variance followed by Student-Newman-Keuls test.) The Annals of Thoracic Surgery 1998 66, 118-123DOI: (10.1016/S0003-4975(98)00355-5)

Fig 2 Cerebral oxygen delivery (CDo2) and cerebral metabolic rate for oxygen (CMRo2) versus mean arterial pressure (MAP). Values (mL · 100 g−1 · min−1) are mean ± standard deviation. Regression curves for CDo2 and CMRo2 were generated from individual values for each variable at MAPs from 35 to 50 mm Hg and for MAPs from 60 to 70 mm Hg. The reduction in MAP to 50 mm Hg revealed in a significant decrease in CDo2 whereas CMRo2 was maintained by an increase in cerebral oxygen extraction ratio until MAP of 45 mm Hg. (∗p < 0.05 versus MAP of 60 mm Hg by repeated measures analysis of variance followed by Student-Newman-Keuls test.) The Annals of Thoracic Surgery 1998 66, 118-123DOI: (10.1016/S0003-4975(98)00355-5)