It Takes Two Binding Sites for Calcineurin and NFAT to Tango Jun O. Liu, Benjamin A. Nacev, Jing Xu, Shridhar Bhat  Molecular Cell  Volume 33, Issue 6, Pages 676-678 (March 2009) DOI: 10.1016/j.molcel.2009.03.005 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 The Sites of Interactions between Calcineurin and NFAT Shown are the crystal structure of calcineurin and the domain structures of the NFAT regulatory domain. Color codes: blue, the catalytic subunit of calcineurin lacking the C terminus; green, the regulatory domain of calcineurin; yellow, the PxIxIT motif of NFAT and its binding site on the catalytic domain of calcineurin; orange, the regulatory domain of NFAT and the active site of calcineurin; pink, the LxVP motif of NFAT and its binding site on the composite surface of the two subunits of calcineurin; red, NFAT phosphorylation sites. Molecular Cell 2009 33, 676-678DOI: (10.1016/j.molcel.2009.03.005) Copyright © 2009 Elsevier Inc. Terms and Conditions