Pioglitazone administration acutely reduces whole-body energy expenditure in Wistar rats. Pioglitazone administration acutely reduces whole-body energy.

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Pioglitazone administration acutely reduces whole-body energy expenditure in Wistar rats. Pioglitazone administration acutely reduces whole-body energy expenditure in Wistar rats. Pioglitazone (black circles or bar; 30 mg/kg) or vehicle (white circles or bar) was administered 2 h after food withdrawal and data were collected during the next 6 h. A: Oxygen consumption (VO2). B: Carbon dioxide production (VCO2). C: Energy expenditure (EE) calculated from VO2 and VCO2. D: Respiratory exchange ratio (RER) measured as VCO2/VO2. E: Total horizontal and vertical distances traveled by the animals during the 6-h air sampling. Data expressed as means ± SEM, n = 6–7 for calorimetry and n = 13 for locomotor activity. Two-way repeated-measures ANOVA: *P < 0.05 vs. vehicle-treated group. Pio, pioglitazone; Ctl, control. Julien Lamontagne et al. Diabetes 2013;62:2122-2129 ©2013 by American Diabetes Association