IKKβ protects adipocytes from HFD-induced cell death.

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IKKβ protects adipocytes from HFD-induced cell death. IKKβ protects adipocytes from HFD-induced cell death. A: Representative TUNEL staining of epiWAT sections from ND- or HFD-fed IKKβF/F and IKKβΔAd mice. The nuclei were stained with DAPI (blue), and the TUNEL-positive cells were indicated by arrows. Scale bar, 50 μm. B: Representative immunohistochemistry for perilipin of epiWAT sections from ND- or HFD-fed IKKβF/F and IKKβΔAd mice. The nuclei were stained with hematoxylin (blue), and the perilipin-negative adipocytes were indicated by arrows. Scale bar, 100 μm. C: Western blot analysis with the indicated total and phosphorylated (p) antibodies in epiWAT from ND or HFD-fed IKKβF/F and IKKβΔAd mice. Se-Hyung Park et al. Diabetes 2016;65:1616-1629 ©2016 by American Diabetes Association