Immune cell populations associated with type I IFNGS test status and disease activity. Immune cell populations associated with type I IFNGS test status.

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Presentation transcript:

Immune cell populations associated with type I IFNGS test status and disease activity. Immune cell populations associated with type I IFNGS test status and disease activity. Data are mean fold change of baseline flow cytometry measurements±95% CIs of immune cell subsets in IFNGS test-high versus IFNGS test-low patients, patients with Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) ≥10 versus patients with CLASI <10, and patients with Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) ≥10 versus patients with SLEDAI <10. A constant value of 0.5 was added to all data points before a log2 transformation was applied. Statistical analysis was carried out using a Student’s t-test. Significant p-values <0.05 are reported. DC, dendritic cells; IFN, interferon; IFNGS, IFN gene signature; n.s., not significant; WB, whole blood; WBC, white blood cells. Kerry A Casey et al. Lupus Sci Med 2018;5:e000286 ©2018 by Lupus Foundation of America