STDP regulates synchrony in fusiform cells of the guinea pig DCN

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STDP regulates synchrony in fusiform cells of the guinea pig DCN

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Fig. 1 STDP regulates synchrony in fusiform cells of the guinea pig DCN. STDP regulates synchrony in fusiform cells of the guinea pig DCN. (A) Spontaneous activity (SA) was recorded across the fusiform cell (FC) population in 25 guinea pigs for 150 s, followed by 60 s (5 Hz) of bimodal stimulation (BIS) with bimodal intervals (BI) from −20 to +20 ms. SA was recorded again 15 min after BIS for 150 s. (B) Synchrony was assessed by cross-correlations (x-corr) of spikes in FC pairs (FC1 and FC2). SA of FCs shows Poisson distributions in interspike interval histograms (ISIHs). Synchronous unit pairs are defined by threshold cross-correlation coefficients (x-corr coef) of 4 SD (dashed line). (C) In one representative FC unit pair, a BI of −10 ms (auditory preceding somatosensory stimulus by 10 ms; pink) reduced the peak x-corr coef (top), whereas a BI of 10 ms (somatosensory preceding auditory stimulus by 10 ms; blue) increased the peak x-corr coef 15 min after BIS (bottom). (D) Changes in peak x-corr coef for the FC unit pair in (C) are plotted as a function of BI (learning rule). (E) In a different FC unit pair, a BI of −10 ms increased peak x-corr coef (top), whereas a BI of 10 ms decreased peak x-corr coef 15 min after BIS (bottom). (F) For the FC unit pair in (E), changes in x-corr coef after BIS were opposite to that for the FC unit pair in (D). Kendra L. Marks et al., Sci Transl Med 2018;10:eaal3175 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works