Volume 95, Issue 5, Pages (May 2019)

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Volume 95, Issue 5, Pages 1004-1006 (May 2019) Journal club Kidney International Volume 95, Issue 5, Pages 1004-1006 (May 2019) DOI: 10.1016/j.kint.2019.03.008 Copyright © 2019 Terms and Conditions

Figure 1 ASO treatment resulted in a striking and significant improvement in the cystic burden in the JBTS mouse model. Adapted from Ramsbottom SA, Molinari E, Srivastava S, et al. Targeted exon skipping of a CEP290 mutation rescues Joubert syndrome phenotypes in vitro and in a murine model. PNAS. 2018;115:12489–12494. This open-access article is distributed under Creative Commons Attribution-NonCommercial-No Derivatives License 4.0 (CC BY-NC-ND 4.0). To optimize viewing of this image, please see the online version of this article at www.kidney-international.org. Kidney International 2019 95, 1004-1006DOI: (10.1016/j.kint.2019.03.008) Copyright © 2019 Terms and Conditions

Figure 2 Effect of erythrocyte membranes on murine smooth muscle cell calcification ex vivo. Murine aortic rings were incubated in Dulbecco’s modified eagle medium (DMEM), osteogenic medium (OM), with or without red blood cell (RBC) membranes (0.5%, 1.0%, or 2.0% of total RBC membrane protein) for 7 days. Aortic rings were embedded in paraffin and 5 μm-thick cross sections stained with Alizarin red (red signal). Mouse bone was used as positive control. Representative findings (a; ×400 magnification) and the results of the quantitative analysis of 3 to 5 aortic rings per variable (b) are shown. ***P < 0.001. Results shown in (b) were analyzed using 1-way analysis of variance followed by the Šidák multiple comparisons test. Reprinted with permission from Tziakas DN, Chalikias G, Pavlaki M, et al. Lysed erythrocyte membranes promote vascular calcification: possible role of erythrocyte-derived nitric oxide [e-pub ahead of print]. Available at: https://doi.org/10.1161/CIRCULATIONAHA.118.037166. Accessed March 22, 2019. Copyright © 2019 Circulation. To optimize viewing of this image, please see the online version of this article at www.kidney-international.org. Kidney International 2019 95, 1004-1006DOI: (10.1016/j.kint.2019.03.008) Copyright © 2019 Terms and Conditions