Concentrations in tissues and body fluids for each systemic antifungal agent relative to its concentration in plasma. Concentrations in tissues and body.

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Presentation transcript:

Concentrations in tissues and body fluids for each systemic antifungal agent relative to its concentration in plasma. Concentrations in tissues and body fluids for each systemic antifungal agent relative to its concentration in plasma. X, human data; O, animal data. Colors illustrate differing ratios; multiple colors within a column give the range of published data. Red, from below level of detection to ≤0.5 times the plasma concentration; yellow, from >0.5 times to ≤5 times the plasma concentration; green, >5 times the plasma concentration; white, no data. ●, pleural fluid, buccal mucosa, or pancreatic pseudocyst; open diamond, based on autopsy data and human pharmacokinetics; Ω, wound fluid; o2, only detected in inflamed eyes; o3, bronchial secretions; x3, below level of detection in bronchial secretions; o4, pulmonary lymph; x5, bronchial biopsy specimen. Timothy Felton et al. Clin. Microbiol. Rev. 2014; doi:10.1128/CMR.00046-13