An experimental model of chronic myocardial hibernation

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Presentation transcript:

An experimental model of chronic myocardial hibernation James D St. Louis, MD, G.Chad Hughes, MD, Alan P Kypson, MD, Timothy R DeGrado, PhD, Carolyn L Donovan, MD, R.Edward Coleman, MD, Bangliang Yin, MD, Charles Steenbergen, MD, PhD, Kevin P Landolfo, MD, James E Lowe, MD The Annals of Thoracic Surgery Volume 69, Issue 5, Pages 1351-1357 (May 2000) DOI: 10.1016/S0003-4975(00)01130-9

Fig 1 Coronary angiogram demonstrating experimental preparation with location of hydraulic occluder (radiolucent and not seen) and ultrasonic flow probe around proximal left circumflex coronary artery (LCX). Note high-grade stenosis of proximal LCX. (LAD = left anterior descending coronary artery.) The Annals of Thoracic Surgery 2000 69, 1351-1357DOI: (10.1016/S0003-4975(00)01130-9)

Fig 2 (A) Representative positron emission tomographic 13N-labeled ammonia perfusion scan performed 14 days after occlusion demonstrating a flow defect in lateral and posteroinferior walls of left ventricle as seen on short-axis view. (B) Corresponding 18F-fluorodeoxyglucose uptake scan showing a relative increase in glucose use in region of flow defect consistent with preserved myocardial viability. The Annals of Thoracic Surgery 2000 69, 1351-1357DOI: (10.1016/S0003-4975(00)01130-9)

Fig 3 Representative transverse slice of midsection of left ventricle stained with Monastral blue (left anterior descending coronary artery distribution) and triphenyl tetrazolium chloride (TTC) (left circumflex coronary artery distribution) demonstrating no infarction within area-at-risk (right coronary artery distribution not injected). Viable tissue stains brick red with TTC; areas of infarction are not stained. The Annals of Thoracic Surgery 2000 69, 1351-1357DOI: (10.1016/S0003-4975(00)01130-9)

Fig 4 Electron microscopic sections from representative animal 14 days after occlusion. (A) Hibernating left circumflex coronary artery region. Note loss of contractile elements within viable cardiomyocytes (arrowheads). These changes are most prominent in the perinuclear area. (B) On higher power, large areas of glycogen accumulation (G) are visible within the areas of sarcomere loss along with numerous small mitochondria (M). (C) Nonischemic anteroseptal region demonstrating normal ultrastructure. (A and C, ×900 before 57.3% reduction; B, ×7,100 before 48.7% reduction.) (N = nucleus.) The Annals of Thoracic Surgery 2000 69, 1351-1357DOI: (10.1016/S0003-4975(00)01130-9)