Crystal structure of DS-A. 02:01 ESO 9V and WT-A

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Presentation transcript:

Crystal structure of DS-A. 02:01 ESO 9V and WT-A Crystal structure of DS-A*02:01 ESO 9V and WT-A*02:01 ESO 9V in complex with 1G4. Crystal structure of DS-A*02:01 ESO 9V and WT-A*02:01 ESO 9V in complex with 1G4. (A) Overlay of WT and DS-A*02:01 structure with focus on peptide and amino acid side-chain orientation. (B) Close-up of the F-pocket and the introduced disulfide bond between α1 and α2. (C) Overlay of the 1G4 CDR loops interacting with the peptide and the MHC backbone. (D) Overlay of both crystal structures from a lateral perspective. Andreas Moritz et al. Sci. Immunol. 2019;4:eaav0860 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works