Effects of rhein on FBG (A) and glucose intolerance (B) in db/db mice.

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Effects of rhein on FBG (A) and glucose intolerance (B) in db/db mice. Effects of rhein on FBG (A) and glucose intolerance (B) in db/db mice. Mice were orally treated with rhein (120 mg/kg) or vehicle for 8 weeks. FBG was measured weekly. After the last administration, half of them were used for oral glucose intolerance experiments and the others given a 1-month recovery period in which FBG was also determined weekly. Mice treated with or without rhein received an oral glucose challenge (1 g/kg). Blood samples were collected from the tail vein at 0, 30, 60, and 120 min. Blood glucose levels were determined using the blood glucose meter. Data are presented as mean ± SD (n = 6). *P < 0.05, compared with mice treated with vehicle control. 20 × 13 mm (300 × 300 DPI). Jing Liu et al. Diabetes 2013;62:3927-3935 ©2013 by American Diabetes Association