Peanut-specific IgE antibodies in asymptomatic Ghanaian children possibly caused by carbohydrate determinant cross-reactivity Abena S. Amoah, MSc, Benedicta.

Slides:

Advertisements

Similar presentations

In vivo assessment with prick-to-prick testing and double-blind, placebo-controlled food challenge of allergenicity of apple cultivars Suzanne T.H.P. Bolhaar,

Advertisements

Peanut-specific IgE antibodies in asymptomatic Ghanaian children possibly caused by carbohydrate determinant cross-reactivity Abena S. Amoah, MSc, Benedicta.

Detection of novel occupational wood allergens in locust wood dust (Robinia pseudoacacia L.) Sabine Kespohl, PhD, Rolf Merget, MD, Axel Overlack, MD,

Repeated low-dose intradermal allergen injection suppresses allergen-induced cutaneous late responses Giuseppina Rotiroti, MD, Mohamed Shamji, PhD, Stephen.

Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: A BAMSE/MeDALL study Anna.

Pru p 3 acts as a strong sensitizer for peanut allergy in Spain

The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.

Birch pollen–related food allergy: Clinical aspects and the role of allergen-specific IgE and IgG4 antibodies Marija Geroldinger-Simic, MD, Thomas Zelniker,

Mauritis J. van der Veen, MDa,b, Ronald van Ree, PhDb, Rob C

High-titer IgE antibody specific for pollen allergens in northern California is associated with both wheezing and total serum IgE Elizabeth A. Erwin,

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD

Giant ragweed specific immunotherapy is not effective in a proportion of patients sensitized to short ragweed: Analysis of the allergenic differences.

IgE cross-reactivity between the major peanut allergen Ara h 2 and the nonhomologous allergens Ara h 1 and Ara h 3 Merima Bublin, PhD, Maria Kostadinova,

Major rabbit allergen Ory c 3: What could be its possible role as a sensitizing agent in real life? Gennaro Liccardi, MD, Antonello Salzillo, MD, Maria.

Delineating the specificity of an IgE-encoding transcriptome

David A. Khan, MD Journal of Allergy and Clinical Immunology

Julie Wang, MD, James H. Godbold, PhD, Hugh A. Sampson, MD

Dorothy M. Ryan, MD, Stephen J. Fowler, MD, Robert M. Niven, MD

Is 9 more than 2 also in allergic airway inflammation?

Marjolein Wensing, MDa, Jaap H. Akkerdaas, MScb, W

Firdaus Hamid, MD, PhD, Serge A. Versteeg, BSc, Aprilianto E

Luud J. W. J. Gilissen, PhD, Suzanne T. H. P

Robert G. Hamilton, PhD, John Oppenheimer, MD

In vivo allergenic activity of a hypoallergenic mutant of the major fish allergen Cyp c 1 evaluated by means of skin testing Nikolaos Douladiris, MD,

Component-resolved diagnosis of baker's allergy based on specific IgE to recombinant wheat flour proteins∗ Ingrid Sander, PhD, Hans-Peter Rihs, PhD,

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

The prevalence of food allergy: A meta-analysis

Allergy testing in predicting outcome of open food challenge to peanut

Prediction of peanut allergy in adolescence by early childhood storage protein-specific IgE signatures: The BAMSE population-based birth cohort Anna.

Etiology of asthma exacerbations

Comparable IgE reactivity to natural and recombinant Api m 1 in cross-reactive carbohydrate determinant–negative patients with bee venom allergy Thilo.

Peanut epitopes for IgE and IgG4 in peanut-sensitized children in relation to severity of peanut allergy Annebeth E. Flinterman, MD, Edward F. Knol,

ImmunoCAP cellulose displays cross-reactive carbohydrate determinant (CCD) epitopes and can cause false-positive test results in patients with high anti-CCD.

Serum tryptase levels in atopic and nonatopic children

Component-resolved diagnosis of kiwifruit allergy with purified natural and recombinant kiwifruit allergens Merima Bublin, PhD, Marina Pfister, MD, Christian.

Peanut oral immunotherapy modifies IgE and IgG4 responses to major peanut allergens Brian P. Vickery, MD, Jing Lin, PhD, Michael Kulis, PhD, Zhiyan Fu,

Epicutaneous immunotherapy for peanut allergy modifies IgG4 responses to major peanut allergens Stef J. Koppelman, PhD, Aurélie Peillon, MSc, Wenceslas.

Kerstin Bauermeister, MSc, Barbara K

Melanie Albrecht, MSc, Yvonne Kühne, MSc, Barbara K

Cephalosporin Side Chain Cross-reactivity

Different IgE recognition of mite allergen components in asthmatic and nonasthmatic children Yvonne Resch, MSc, Sven Michel, MSc, Michael Kabesch, MD,

Skin test evaluation of a novel peptide carrier–based vaccine, BM32, in grass pollen– allergic patients Verena Niederberger, MD, Katharina Marth, MD,

Cockroach allergens: Coping with challenging complexity

Autophagy: Nobel Prize 2016 and allergy and asthma research

The Editors' Choice Journal of Allergy and Clinical Immunology

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Mauritis J. van der Veen, MDa,b, Ronald van Ree, PhDb, Rob C

Association between specific timothy grass antigens and changes in TH1- and TH2-cell responses following specific immunotherapy Véronique Schulten, PhD,

Birch pollen–related food allergy: Clinical aspects and the role of allergen-specific IgE and IgG4 antibodies Marija Geroldinger-Simic, MD, Thomas Zelniker,

Peach allergy in China: A dominant role for mugwort pollen lipid transfer protein as a primary sensitizer Zhong-Shan Gao, PhD, Zhao-Wei Yang, BSc, Shan-Dong.

Cat IgA, representative of new carbohydrate cross-reactive allergens

Benjamin Chaigne, MD, Hervé Watier, MD, PhD

Martin Brasholt, MD, Florent Baty, PhD, Hans Bisgaard, MD, DMSci

Sensitization to Cor a 9 and Cor a 14 is highly specific for a hazelnut allergy with objective symptoms in Dutch children and adults Laury J.N. Masthoff,

Allergy to human seminal fluid: Cross-reactivity with dog dander

Peanut oral immunotherapy decreases IgE to Ara h 2 and Ara h 6 but does not enhance sensitization to cross-reactive allergens Riikka Uotila, MD, Anna.

Microarray immunoassay: Association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes Wayne G. Shreffler, MD,

A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay Jing Lin, PhD, Francesca M. Bruni,

Lipid transfer protein–linked hazelnut allergy in children from a non-Mediterranean birch- endemic area Annebeth E. Flinterman, MD, Jaap H. Akkerdaas,

Profilin (Che a 2) and polcalcin (Che a 3) are relevant allergens of Chenopodium album pollen: Isolation, amino acid sequences, and immunologic properties

Abena S. Amoah, PhD, Elias K. Asuming-Brempong, PhD, Benedicta B

Asthma: The past, future, environment, and costs

Repeated low-dose intradermal allergen injection suppresses allergen-induced cutaneous late responses Giuseppina Rotiroti, MD, Mohamed Shamji, PhD, Stephen.

Placental transfer of allergen-specific IgG but not IgE from a specific immunotherapy– treated mother Sabine Flicker, PhD, Katharina Marth, MD, Heinz.

Galactose-alpha-1,3-galactose sensitization is a prerequisite for pork-kidney allergy and cofactor-related mammalian meat anaphylaxis Jörg Fischer, MD,

Peanut-specific IgE antibodies in asymptomatic Ghanaian children possibly caused by carbohydrate determinant cross-reactivity Abena S. Amoah, MSc, Benedicta.

The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.

Allergen-specific IgG antibody levels modify the relationship between allergen-specific IgE and wheezing in childhood Adnan Custovic, MD, PhD, Lars Soderstrom,

Natural history of cow’s milk allergy

Carl Hamsten, MSc, PhD, Thi Anh T

Presentation transcript:

Peanut-specific IgE antibodies in asymptomatic Ghanaian children possibly caused by carbohydrate determinant cross-reactivity Abena S. Amoah, MSc, Benedicta B. Obeng, BSc, Irene A. Larbi, MSc, Serge A. Versteeg, BSc, Yvonne Aryeetey, BSc, Jaap H. Akkerdaas, PhD, Laurian Zuidmeer, PhD, Jonas Lidholm, PhD, Montserrat Fernández-Rivas, MD, PhD, Franca C. Hartgers, PhD, Daniel A. Boakye, PhD, Ronald van Ree, PhD, Maria Yazdanbakhsh, PhD Journal of Allergy and Clinical Immunology Volume 132, Issue 3, Pages 639-647 (September 2013) DOI: 10.1016/j.jaci.2013.04.023 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Overlap between reported adverse reactions to peanut and peanut sensitization (IgE levels and SPT responses) for subjects with complete data for allergy-related parameters (n = 1004). Journal of Allergy and Clinical Immunology 2013 132, 639-647DOI: (10.1016/j.jaci.2013.04.023) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 A, Measurement of specific IgE levels to whole peanut extract, recombinant peanut allergens, profilin, and the CCD marker bromelain in a subset (n = 43). Median specific IgE levels are indicated by black lines. The dotted line shows an IgE sensitization cutoff of 0.35 kU/L. B, Correlation between peanut-specific IgE and CCD-specific IgE levels. Open circles indicate subjects with IgE to rAra h 9 of greater than 1.5 kU/L. Journal of Allergy and Clinical Immunology 2013 132, 639-647DOI: (10.1016/j.jaci.2013.04.023) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Inhibition of IgE binding to whole peanut by bromelain and S haematobium SEA by using pooled sera (n = 17). The figure shows that IgE binding to whole peanut extract was almost completely inhibited by bromelain (diamonds) and S haematobium SEA (triangles), respectively. Journal of Allergy and Clinical Immunology 2013 132, 639-647DOI: (10.1016/j.jaci.2013.04.023) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 BHR assay results. BHR induced by peanut extract (solid circles), S haematobium SEA (open triangles), and Ara h 9 (open circles). A and B, Results for 2 subjects with high IgE titers against peanut and CCD. C and D, Results for 2 subjects with high IgE titers against peanut and Ara h 9 but low IgE titers against CCDs. Journal of Allergy and Clinical Immunology 2013 132, 639-647DOI: (10.1016/j.jaci.2013.04.023) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Journal of Allergy and Clinical Immunology 2013 132, 639-647DOI: (10.1016/j.jaci.2013.04.023) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Journal of Allergy and Clinical Immunology 2013 132, 639-647DOI: (10.1016/j.jaci.2013.04.023) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions