Abena S. Amoah, PhD, Elias K. Asuming-Brempong, PhD, Benedicta B

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Presentation transcript:

Identification of dominant anti-glycan IgE responses in school children by glycan microarray Abena S. Amoah, PhD, Elias K. Asuming-Brempong, PhD, Benedicta B. Obeng, BSc, Serge A. Versteeg, BSc, Irene A. Larbi, PhD, Yvonne Aryeetey, MPhil, Thomas A.E. Platts-Mills, MD, PhD, FRS, Adriano Mari, MD, Katarzyna Brzezicka, PhD, Ben A. Gyan, PhD, Mohamed Mutocheluh, PhD, Daniel A. Boakye, PhD, Niels-Christian Reichardt, PhD, Ronald van Ree, PhD, Cornelis H. Hokke, PhD, Angela van Diepen, PhD, Maria Yazdanbakhsh, PhD Journal of Allergy and Clinical Immunology Volume 141, Issue 3, Pages 1130-1133 (March 2018) DOI: 10.1016/j.jaci.2017.09.040 Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A, IgE responses to selected N-glycan motifs. N-glycan structures eliciting the greatest IgE binding among Ghanaian children were identified by heatmap. Responses to these structures are shown among Ghanaian children (stratified by school category) and Italian pollen-allergic controls. Four additional structures with key variants were included for comparison and are indicated on the figure. *Kruskal-Wallis test of between-area differences in IgE response among Ghanaian subjects only (P < .05). #Structures included for comparison. **Response missing for 1 Italian pollen-allergic control for structure G37 due to smear on the specific microarray slide that obstructed the reading of microarray spots for this structure only. B, IgE responses to α-1,3-gal motifs. IgE reactivities to α-1,3-gal motifs are shown among Ghanaian children (stratified by school category) and US meat-allergic controls. Lewis X saccharide (G127) was included as a control for small synthetic oligosaccharides. *Kruskal-Wallis test of between-area differences in IgE response among Ghanaian subjects only (P < .05). #Structure included for comparison. Journal of Allergy and Clinical Immunology 2018 141, 1130-1133DOI: (10.1016/j.jaci.2017.09.040) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Correlations between IgE to bromelain measured by ImmunoCAP and IgE to N-glycans measured by glycan microarray in Ghanaian children. Correlation between IgE to bromelain and core xylose only (structure G34) (A), core α-1,3 fucose only (structure G73) (B) and core α-1,3 fucose + core xylose (structure G37) (C). Journal of Allergy and Clinical Immunology 2018 141, 1130-1133DOI: (10.1016/j.jaci.2017.09.040) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Journal of Allergy and Clinical Immunology 2018 141, 1130-1133DOI: (10.1016/j.jaci.2017.09.040) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Journal of Allergy and Clinical Immunology 2018 141, 1130-1133DOI: (10.1016/j.jaci.2017.09.040) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Journal of Allergy and Clinical Immunology 2018 141, 1130-1133DOI: (10.1016/j.jaci.2017.09.040) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Journal of Allergy and Clinical Immunology 2018 141, 1130-1133DOI: (10.1016/j.jaci.2017.09.040) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions