Reversal of Morphine with Naloxone Precipitates Haloperidol-Induced Extrapyramidal Side Effects  Shu-Lin Guo, MD  Journal of Pain and Symptom Management  Volume 31, Issue 5, Pages 391-392 (May 2006) DOI: 10.1016/j.jpainsymman.2006.03.002 Copyright © 2006 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 1 The temporal course of repeated naloxone reversal and coexisting attacks of extrapyramidal side effects. The pupil size represents the interaction between morphine (M) and naloxone (N). The occurrence of oculogyric crisis (O, ■) and torticollis (T, □) was closely related to the reversal of pinpoint size pupils by naloxone. Three identical episodes were observed after naloxone injections. Journal of Pain and Symptom Management 2006 31, 391-392DOI: (10.1016/j.jpainsymman.2006.03.002) Copyright © 2006 U.S. Cancer Pain Relief Committee Terms and Conditions