Increased anti-DNA Abs in 2KO-Bcl6TC mice.

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Increased anti-DNA Abs in 2KO-Bcl6TC mice. Increased anti-DNA Abs in 2KO-Bcl6TC mice. Naive 10-wk-old WT, IL-2 KO, Bcl6TC, and 2KO-Bcl6TC mice were used to analyze serum Ab responses for reactivity to dsDNA. Bar graphs on the left show normalized results over all experiments in which OD values at 1:25 dilutions of serum are normalized relative to the average OD value for IL-2 KO serum, which is set to 1.0 for each experiment. Line graphs on the right show sample ELISA results with titrations for individual sets of sera. Serum was tested for (A) anti-dsDNA IgG and (B) anti-dsDNA IgA. n = 4–6 mice, and each experiment was repeated at least three times. The p values were calculated by t test, in which *p < 0.05, ***p < 0.0001. Markus M. Xie et al. ImmunoHorizons 2019;3:306-316 Copyright © 2019 The Authors