Activin overexpression leads to keratinocytic cysts and high cell density in the granulation tissue of healed wounds. Activin overexpression leads to keratinocytic.

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Activin overexpression leads to keratinocytic cysts and high cell density in the granulation tissue of healed wounds. Activin overexpression leads to keratinocytic cysts and high cell density in the granulation tissue of healed wounds. Representative microphotographs of haematoxylin- and eosin-stained tissue specimens from 14-day-old full-thickness excisional wounds of wild-type (wt) and K14-activin transgenic (K14-Act) mice are shown. Note the keratinocytic cysts in the granulation tissue (indicated by arrowheads) and the high cell density, which is reflected by the multiple nuclei (blue). The transgene-derived activin is secreted by basal keratinocytes (arrow); it acts in an autocrine manner on keratinocytes and in a paracrine manner on stromal cells (dashed arrows). Triangle, wound edge; GT, Granulation tissue; HE, Hyperproliferative wound epidermis. Scale bar: 100 µm. Maria Antsiferova, and Sabine Werner J Cell Sci 2012;125:3929-3937 © 2012. Published by The Company of Biologists Ltd