10. Drug allergy Journal of Allergy and Clinical Immunology

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10. Drug allergy Journal of Allergy and Clinical Immunology Rebecca S. Gruchalla, MD, PhD Journal of Allergy and Clinical Immunology Volume 111, Issue 2, Pages S548-S559 (February 2003) DOI: 10.1067/mai.2003.93 Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 1 General structure of penicillins and structures of the major and minor penicillin antigenic-allergenic determinants, showing point of attachment of the drug to the carrier. From Baldo B. Penicillins and cephalosporins as allergens—structural aspects of recognition and cross-reactions. Clin Exp Allergy 1999;29:745. Used with permission. Journal of Allergy and Clinical Immunology 2003 111, S548-S559DOI: (10.1067/mai.2003.93) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 2 Structural similarities and differences of penicillin. From Baldo B. Penicillins and cephalosporins as allergens—structural aspects of recognition and cross-reactions. Clin Exp Allergy 1999;29:745. Used with permission. Journal of Allergy and Clinical Immunology 2003 111, S548-S559DOI: (10.1067/mai.2003.93) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 3 Structural similarities and differences of cephalosporins. From Baldo B. Penicillins and cephalosporins as allergens—structural aspects of recognition and cross-reactions. Clin Exp Allergy 1999;29:745. Used with permission. Journal of Allergy and Clinical Immunology 2003 111, S548-S559DOI: (10.1067/mai.2003.93) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 4 Sulfonamide metabolism. From Gruchalla R, Pesenko, RD, Do, TT, Skiest, DJ. Sulfonamide-induced reactions in patients with AIDS—the role of covalent protein haptenation. J Allergy Clin Immunol 1998;101:372. Used with permission. Journal of Allergy and Clinical Immunology 2003 111, S548-S559DOI: (10.1067/mai.2003.93) Copyright © 2003 Mosby, Inc. Terms and Conditions