Closed-loop experiments to probe the range of stimulus sensitivity.

Slides:

Advertisements

Similar presentations

Multi-Electrode Arrays (MEAs) March 25, Introduction Multi-electrode Arrays, or MEAs, are quickly becoming a common tool to investigate patterns.

Advertisements

A Precisely Timed Asynchronous Pattern of ON and OFF Retinal Ganglion Cell Activity during Propagation of Retinal Waves Daniel Kerschensteiner, Rachel.

Grid Cells for Conceptual Spaces?

Sensitivity of RNA‐seq.

Predicting Every Spike

Structures of Neural Correlation and How They Favor Coding

Volume 81, Issue 4, Pages (February 2014)

Chenguang Zheng, Kevin Wood Bieri, Yi-Tse Hsiao, Laura Lee Colgin

Mismatch Receptive Fields in Mouse Visual Cortex

Volume 66, Issue 6, Pages (June 2010)

Retinal Representation of the Elementary Visual Signal

The Neural Code of the Retina

Dynamic Processes Shape Spatiotemporal Properties of Retinal Waves

Neural Circuit Inference from Function to Structure

Kenji Mizuseki, György Buzsáki Cell Reports

Volume 82, Issue 4, Pages (May 2014)

Volume 49, Issue 3, Pages (February 2006)

Encoding of Vibrissal Active Touch

Volume 71, Issue 4, Pages (August 2011)

Jianing Yu, David Ferster Neuron

Nicolas Catz, Peter W. Dicke, Peter Thier Current Biology

The Challenges Natural Images Pose for Visual Adaptation

Motor Learning with Unstable Neural Representations

Amanda H. Lewis, Alisa F. Cui, Malcolm F. McDonald, Jörg Grandl

Volume 65, Issue 4, Pages (February 2010)

Neuronal Selectivity and Local Map Structure in Visual Cortex

Ana Parabucki, Ilan Lampl Cell Reports

Ethan S. Bromberg-Martin, Masayuki Matsumoto, Okihide Hikosaka Neuron

Greg Schwartz, Sam Taylor, Clark Fisher, Rob Harris, Michael J. Berry

Xiaomo Chen, Marc Zirnsak, Tirin Moore Cell Reports

The Temporal Correlation Hypothesis of Visual Feature Integration

Volume 14, Issue 4, Pages (February 2016)

Origin and Dynamics of Extraclassical Suppression in the Lateral Geniculate Nucleus of the Macaque Monkey Henry J. Alitto, W. Martin Usrey Neuron Volume.

Timing, Timing, Timing: Fast Decoding of Object Information from Intracranial Field Potentials in Human Visual Cortex Hesheng Liu, Yigal Agam, Joseph.

Daniel E. Winkowski, Eric I. Knudsen Neuron

ABLE detects synchronously spiking, densely packed cells from mouse in vitro imaging data. ABLE detects synchronously spiking, densely packed cells from.

Implicit adaptation generalizes around the aiming location (30° CCW)

A, Multivariate glm analysis for the aggregate observer (for the interval range within –450 and 250 ms from action execution). A, Multivariate glm analysis.

Gabe J. Murphy, Fred Rieke Neuron

Target-Specific Glycinergic Transmission from VGluT3-Expressing Amacrine Cells Shapes Suppressive Contrast Responses in the Retina Nai-Wen Tien, Tahnbee.

by Kenneth W. Latimer, Jacob L. Yates, Miriam L. R

Grid Cells and Neural Coding in High-End Cortices

Volume 37, Issue 3, Pages (February 2003)

CT and CI odor responses.

Spatial statistics of X-ray volumes reveal layering and spatially diverse distribution of cell bodies. Spatial statistics of X-ray volumes reveal layering.

Volume 83, Issue 1, Pages (July 2014)

Multineuronal Firing Patterns in the Signal from Eye to Brain

Basal synaptic transmission and climbing fiber activity remained intact in PNs of STIM1PKO mice. Basal synaptic transmission and climbing fiber activity.

Discriminator rats exhibited an enhanced coherence between the Te1 and the PL cortex in the slow-gamma band. Discriminator rats exhibited an enhanced coherence.

The Fisher information predicts the experimentally measured sensitivity. The Fisher information predicts the experimentally measured sensitivity. A, Sensitivity.

Recording CAPs from mouse optic nerve.

Learning rates and CR latency data for mice trained at trace 50–350 or trace 50–450. Learning rates and CR latency data for mice trained at trace 50–350.

Template application to detect KC-like activity.

Tuning width distributions.

Short-term synaptic depression in SCN neurons during stimulus train application. Short-term synaptic depression in SCN neurons during stimulus train application.

Relationship between saccade duration, endpoint accuracy, and expected value of reward. Relationship between saccade duration, endpoint accuracy, and expected.

Spatial-Temporal Patterns of Retinal Waves Underlying Activity-Dependent Refinement of Retinofugal Projections Ben K. Stafford, Alexander Sher, Alan.

Light illumination activates primary afferents with conduction velocity in a range of Aβ fibers. Light illumination activates primary afferents with conduction.

Neurons spike at a consistent phase of the oscillations in the LFP

Responses measured by BOLD fMRI in areas V1, V2, V3, and MT+ as two subjects (S2, gray; S3, black) switched between the speed and the contrast discrimination.

Calibration of the voltage dependence of spine ΔF/F using optical recordings in spines of bAPs. Calibration of the voltage dependence of spine ΔF/F using.

Neurophysiological recordings.

Neural Correlates of Vibrissa Resonance

Phase-amplitude coupling is most prominent during REM sleep.

Grand-averaged ERPs across (A) left hemisphere electrodes (P5, P7, P9, PO3, PO7, and O1) and (B) right hemisphere electrodes (P6, P8, P10, PO4, PO8, and.

Binocular neurons mismatched in spatial frequency are also mismatched in orientation preference. Binocular neurons mismatched in spatial frequency are.

Nonlinear transfer of signal and noise correlations in vivo.

Direction-Selective Dendritic Action Potentials in Rabbit Retina

Differences in MT cell responses between fast and slow sniff cycles.

Volume 16, Issue 4, Pages (July 2016)

Presentation transcript:

Closed-loop experiments to probe the range of stimulus sensitivity. Closed-loop experiments to probe the range of stimulus sensitivity. A, Experimental setup: we stimulated a rat retina with a moving bar. Retinal ganglion cell (RGC) population responses were recorded extracellularly with a multielectrode array. Electrode signals were high-pass filtered and spikes were detected by threshold crossing. We computed the discrimination probability of the population response and adapted the amplitude of the next perturbation. B, left, The neural responses of 60 sorted RGCs are projected along the axis going through the mean response to reference stimulus and the mean response to a large perturbation. Small dots are individual responses, large dots are means. Middle, Mean and standard deviation (in gray) of response projections for different amplitudes of an example perturbation shape. Right, Distributions of the projected responses to the reference (blue), and to small (purple) and large (red) perturbations. Discrimination is high when the distribution of the perturbation is well separated from the distribution of the reference. C, Discrimination probability as a function of amplitude A. The discrimination increases as an error function, , with (gray line: fit). Ticks on the x-axis show the amplitudes that have been tested during the closed-loop experiment. Ulisse Ferrari et al. eNeuro 2017;4:ENEURO.0166-17.2017 ©2017 by Society for Neuroscience