Activation of LHAGal neurons reduces compulsive burying.

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Activation of LHAGal neurons reduces compulsive burying. Activation of LHAGal neurons reduces compulsive burying. In contrast, LHAGABA activation increases burying. A, Marble-burying behavior following CNO injection (1 mg/kg) in LHAGal DREADD-Gq mice (n = 9) is decreased compared with LHAGal Control mice (n = 6). B, Marble-burying behavior following CNO injection (0.1 mg/kg) LHAVgat DREADD-Gq mice (n = 8) is increased compared with LHAVgat Control mice (n = 4). All data are represented as mean ± SEM, paired t test, *p < 0.05, ***p < 0.001. C, Representative images of marble placement at test start (far left), and at the end of 30 min testing period for LHAGal control (left), LHAGal DREADD-Gq (middle), LHAVgat control (right), and LHAVgat DREADD-Gq (far right). LHA, lateral hypothalamic area; DREADD, Designer Receptors Exclusively Activated by Designer Drugs; Gal, galanin. Emily Qualls-Creekmore et al. J. Neurosci. 2017;37:6053-6065 ©2017 by Society for Neuroscience