Modulation of IL-10, IL-12, and IFN-γ in the Epidermis of Hairless Mice by UVA (320– 400 nm) and UVB (280–320 nm) Radiation Jie Shen, Shisan Bao, Vivienne.

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Modulation of IL-10, IL-12, and IFN-γ in the Epidermis of Hairless Mice by UVA (320– 400 nm) and UVB (280–320 nm) Radiation Jie Shen, Shisan Bao, Vivienne E. Reeve Journal of Investigative Dermatology Volume 113, Issue 6, Pages 1059-1064 (December 1999) DOI: 10.1046/j.1523-1747.1999.00782.x Copyright © 1999 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Immunohistochemical demonstration of epidermal cytokine expression at critical time points postirradiation. Peak expression at 3 d postirradiation of IL-10 (induced by UVB, but not by UVA or UVA + UVB) and IL-12 (induced by UVA, but not by UVB), and of IFN-γ (induced by UVA but not by UVB) at 1 d postirradiation. Constitutive cytokine staining is also shown (Non-UV), along with the isotype control staining (Control). Journal of Investigative Dermatology 1999 113, 1059-1064DOI: (10.1046/j.1523-1747.1999.00782.x) Copyright © 1999 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Post-irradiation time course of the expression of IL-10 quantitated by image analysis. Skin sections were analyzed before (Non-UV), immediately following (0 d), and at daily intervals for 5 d following exposure to UVA, UVB, or UVA + UVB radiation. Points are the mean ±SD of at least 30 fields from each section, taken from three mice per treatment. Journal of Investigative Dermatology 1999 113, 1059-1064DOI: (10.1046/j.1523-1747.1999.00782.x) Copyright © 1999 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Time course of immunopositive IL-10 expression in epidermis following UVB and UVA + UVB irradiation. (a) UVB; (b) UVA + UVB. A, immediately postirradiation; B, C, D, E, F at 1 d, 2 d, 3 d, 4 d, and 5 d postirradiation, respectively. Journal of Investigative Dermatology 1999 113, 1059-1064DOI: (10.1046/j.1523-1747.1999.00782.x) Copyright © 1999 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 4 Post-irradiation time course of the expression of IL-12 quantitated by image analysis. Skin sections were analyzed before (Non-UV), immediately following (0 d), and at daily intervals for 5 d following exposure to UVA, UVB, or UVA + UVB radiation. Points are the mean ±SD of at least 30 fields from each section, taken from three mice per treatment. Journal of Investigative Dermatology 1999 113, 1059-1064DOI: (10.1046/j.1523-1747.1999.00782.x) Copyright © 1999 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 5 Post-irradiation time course of the expression of IFN-γ quantitated by image analysis. Skin sections were analyzed before (Non-UV), immediately following (0 d), and at daily intervals for 5 d following exposure to UVA, UVB, or UVA + UVB radiation. Points are the mean ±SD of at least 30 fields from each section, taken from three mice per treatment. Journal of Investigative Dermatology 1999 113, 1059-1064DOI: (10.1046/j.1523-1747.1999.00782.x) Copyright © 1999 The Society for Investigative Dermatology, Inc Terms and Conditions