An in vivo murine model of rosiglitazone use in pregnancy

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An in vivo murine model of rosiglitazone use in pregnancy Denise B. Klinkner, M.D., Hyun J. Lim, Ph.D., Estil Y. Strawn, M.D., Keith T. Oldham, M.D., Tara L. Sander, Ph.D. Fertility and Sterility Volume 86, Issue 4, Pages 1074-1079 (October 2006) DOI: 10.1016/j.fertnstert.2006.03.024 Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

FIGURE 1 Rosiglitazone effect on embryogenesis. Two-cell murine embryos were treated with 10 μM rosiglitazone for 72 hours and then scored for stage of blastocyst development and compared with dimethyl sulfoxide carrier control. Of the control embryos, 100% reached blastocyst stage, and 100% of the rosiglitazone-treated embryos reached blastocyst stage. None of the diethyl maleate embryos reached blastocyst stage. Klinkner. Rosiglitazone use in murine pregnancy. Fertil Steril 2006. Fertility and Sterility 2006 86, 1074-1079DOI: (10.1016/j.fertnstert.2006.03.024) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

FIGURE 2 Mean weekly pup weights. Weights were obtained weekly on control (C), rosiglitazone (R), and human-dosaged–rosiglitazone (HR) pups. No differences were observed between groups. (Analysis of variance with Bonferroni adjustment, P>.05). Klinkner. Rosiglitazone use in murine pregnancy. Fertil Steril 2006. Fertility and Sterility 2006 86, 1074-1079DOI: (10.1016/j.fertnstert.2006.03.024) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions